骨性关节炎早期诊断方法的评价分析

Evaluation and Analysis of Early Diagnosis for Osteoarthritis

骨性关节炎(OA)是最常见的退行性骨关节病,是成年人疼痛、运动功能障碍和致残的常见原因,目前还没有良好的改变或延缓病情的治疗措施。如何早期诊断OA成为风湿病学领域的关键,传统的X线检查确立诊断时软骨已有明显损伤。近年来,磁共振成像、超声、关节镜虽对OA早期诊断具有重要作用,但这些检查方法都是基于软骨形态学变化,有一定的滞后性。生物标志物反映了关节软骨分子水平的变化,能更准确地监测关节软骨的病理改变,从而为OA早期诊断提供重要信息。

Osteoarthritis（OA） is the most common joints degenerative disease. It is the leading cause of pain, motor dysfunction and disability of adults. Relatively few treatments attempt to modify or slow down the disease process. Early detection of OA is a key challenge in the world of rheumatology, since when the diag- nosis of the traditional X-ray examination is established articular cartilage has already had a significant dam- age. Recently, MRI,ultrasound and arthroscopy have made a great progress in early diagnosis of OA, but these methods are based on morphology changes of articular cartilage, to some extent it is still late. Biomarkers refleet changes in the articular cartilage at the molecular level, which can monitor the pathological changes accurately, thus provide important information for early diagnosis of OA.