妊娠高血压患者凝血指标的检测及临床意义

Detection and Clinical Significance of Coagulation Indicators in Patients with Pregnancy-induced Hypertension

目的探讨轻度妊娠高血压(简称妊高征)患者胱抑素C和凝血指标变化,并讨论其临床意义。方法检测71例我院住院轻度妊高征患者和90例健康产妇血清胱抑素C含量和凝血指标(PT、APTT、TT、FIB、),并进行比较。结果妊高征患者胱抑素C浓度(1.61±0.28)mg/L与对照组(1.23±0.32)mg/L相比,显著升高(P<0.05),但肌酐变化不明显。PT、TT显著缩短(P<0.05),FIB含量及AT-Ⅲ百分比均显著增加(均P<0.05),APTT无显著性差异。结论轻度妊高征患者有高凝倾向,且肾功能降低,应引起关注。

Objective To explore the cystatin C and coagulation index changes of mild pregnancy-induced hypertension（ referred to as PIH ） patients, and discuss its clinical significance. Methods Serum cystatin C content and coagulation index （ PT and APTT, TT, and FIB） of 71 hospitalized patients with mild PIH and 90 healthy maternal cases were tested and compared. Results PIH cystatin C concentration （ 1.61 ±0.28 ） mg/Lwas significantly higher than the control group （ 1.23 ±0.32 ） mg/L （ P 〈 0.05 ）, while creatinine did not change significantly. PT,TT were significantly reduced（ P 〈 0.05 ）, the FIB content and the percentage of AT-III were significantly increased （ P 〈 0.05 ） and there was no significant difference in APTT. Conclusion Patients with mild PIH have a hypercoagnlable tendency and decreased renal function, which calls for due attention.