24例阿司匹林性哮喘病例分析

Analysis of 24 Cases of Aspirin-induced Asthma

目的探讨阿司匹林性哮喘(AIA)的临床特点及治疗方法水平,提高对AIA的认识水平。方法选择2005年4月至2011年1月我院收治的AIA患者24例,所有使用布地奈德粉吸入剂(0.0002～0.0004 g,2次/d)进行治疗,针对应用布地奈德粉吸入剂最高推荐剂量仍不能有效控制者采用白三烯受体拮抗剂孟鲁司特(0.01 g/d)进行治疗。比较上述患者治疗前后基础肺功能的变化。结果 16例阿司匹林哮喘患者经布地奈德粉吸入剂能有效缓解病情,肺功能明显改善;8例患者经布地奈德粉吸入剂最高推荐剂量仍不能有效缓解病情,通过白三烯受体拮抗剂孟鲁司特治疗后,患者临床症状得到有效控制,肺功能基本恢复正常。结论糖皮质激素是阿司匹林哮喘的首选治疗方案,对于糖皮质激素不能有效控制阿司匹林哮喘的患者,白三烯受体拮抗剂是有效控制哮喘发作的治疗选择。

Objective To investigate the clinical characteristics and treatments ot aspmn-mctuced asthma（AIA）. Methods 24 AIA patients were selected from April 2005 to January 2011 in our hospital, who were treated with budesonide powder for inhalation（0. 0002-0. 0004 g,2 times/d） ,for the cases of ineffective control of the disease through the application of budesonide powder inhalation with the highest recommended dose, the leukotrieue receptor antagonist montelukast （0.01 g/d）was used as treatment. The baseline pulmo- nary function changes in patients before and after the treatment were compared. Results The conditions of 16 cases treated with budesonide powder for inhalation were effectively alleviated, and the pulmonary function improved significantly. The conditions of 8 cases couldn＇t be effectively alleviated which were treated with the maximum recommended dose of budesonide powder for inhalation, but the clinical symptoms of the cases were effectively controlled when treated with montelukast soudium tablets （]eukotriene receptor antagonists） , and the lung function returned to normal. Conclusion The cortieosteroids are the primary treatment of AIA, as for the cases whose conditions can＇t be effectively controlle by glucocorticoids,leukotrieue receptor antagonists is an effective control of asthma attack.