多种瘤标志物在检测乳腺癌的临床应用

Clinical Application of Various Tumor Markers in the Inspection of Breast Cancer

目的探讨p53、Survivin及Fas三种肿瘤标志物在乳腺癌检测中的应用价值。方法选取48例乳腺癌患者的乳腺癌组织和癌旁乳腺组织,采用免疫组织化学检测方法分别检测其乳腺组织p53、Survivin及Fas的表达,对检测结果进行统计分析,同时对乳腺癌组织中三种标志物的表达与乳腺癌病理分型、肿瘤直径及淋巴结转移的关系进行分析。结果乳腺癌p53、Survivin的阳性表达率和高表达率分别为93.75%和70.83%、89.58%和70.83%,癌旁乳腺组织p53、Survivin的阳性表达率和高表达率分别为60.42%和4.17%、47.92%和4.17%,前者均显著高于后者;乳腺癌组织Fas的阳性表达率和高表达率分别为56.25%和8.33%,癌旁乳腺组织Fas的阳性表达率和高表达率分别为95.83%和66.67%,前者显著低于后者,差异均有统计学意义(P<0.05)。乳腺癌患者p53、Survivin及Fas的阳性表达与肿瘤病理类型、肿瘤直径及淋巴结转移的乳腺癌患无明显相关。结论p53、Survivin在乳腺癌组织中高表达,Fas低表达,可通过检测其水平评估疾病病变程度及预测预后,指导临床采取合理的预防和治疗措施。

Objective To explore the application value of three tumor markers, namley p53, Survivin and Fas in breast cancer detection. Methods 48 cases of patients with breast cancer were selected, p53, Survivin and Fas expression in the cancer tissue and adjacent tissues were tested by immunohistochemical detection method, the detection results were statistically analyzed, and the correlation between the three markers and breast cancer pathological subtype, tumor diameter and lymph node metastasis were analyzed. Results The Survivin p53 positive expression rate and high expression rate were 93.75% and 70.83% ,89.58% and 70.83% in the carcinoma tissue respectively, and in the adjacent tissues were 60.42% and 4.17% ,47. 92% and 4.17% ,the former were both significantly higher than the latter; Fas positive expression rate and high expression rate in the carcinoma tissue were 56.25% and 8.33% respectively, in the adjacent tissues were 95.83 % and 66.67 % respectively, the former significantly lower than the latter,which were all statisti- cally significant differences （ P 〈 0.05 ）. Breast cancer patients, There was no obvious correlation between p53, Survivin Fas positive expression and pathological subtypes, tumor diameter and the lymph node metasta- sis. Conclusion p53, Survivin are highly expressed and Fas is low expressed in breast cancer tissues, through the test of the levels can assess the disease severity and predict the prognosis, guiding the reasonable prevention and treatment in clinic.