摘要
微血管性心绞痛(microvascular angina,MVA)是由于冠状动脉微循环血流失调引起心肌灌注减少造成的,是经常受到忽略的一种胸痛,阻塞性和非阻塞性的心外膜冠状动脉疾病均可存在。通过测定冠状动脉血流储备(coronary flow reserve,CFR),MVA可得到明确诊断。目前MVA的评估主要是通过有创的心导管检查,应用冠状动脉内多普勒导丝可以检测冠状动脉微循环的功能,但过程复杂、耗时,还会给患者带来一定的风险。最近,一种新的冠状动脉造影方法通过测定时间密度曲线以计算CFR是可行的,可替代冠状动脉内多普勒超声。然而,评估CFR的非侵入性检查技术也正在逐步发展,其中包括正电子放射断层扫描、MRI和CT等。反应缺血的定量追踪技术和灌注成像技术可能将进一步增强MVA的诊断,同时可长期监测治疗效果。
Microvascular angina { MVA） can be a cause of significant chest pain. Decreased myocardial perfusion secondary to dys- regulated blood flow in the microvasculature can occur in the presence or absence of obstructive epicardial coronary artery disease. The corre- sponding myocardial ischemia and angina is detected via decreased coronary flow reserve { CFR }. Current assessment of MVA is done through cardiac catheterization by intracoronary Doppler guide wires. However, noninvasive techniques to assess CFR are being developed, including PET, MRI, and CT modalities.
出处
《心血管病学进展》
CAS
2012年第4期498-501,共4页
Advances in Cardiovascular Diseases
