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脑梗死患者血浆内脂素水平的变化及临床意义 被引量:1

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摘要 目的探讨脑梗死患者血浆内脂素水平的变化及其与血糖、血脂、同型半胱氨酸(Hcy)的关系。方法选取脑梗死患者35例和健康对照者32例,分别检测二者血浆内脂素、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、Hcy水平,并分析脑梗死患者Hcy水平与血糖、血脂水平的关系。结果脑梗死患者血浆内脂素水平为(25.14±8.06)μg/L,健康对照者为(18.73±7.05)μg/L,脑梗死患者血浆内脂素水平明显升高(P<0.01)。直线相关性分析显示,血浆内脂素水平与FPG、LDL-C及Hcy均呈正相关(r分别为0.37、0.22、0.39,P<0.05或<0.01)。多元线性逐步回归分析显示,FPG、LDL-C及Hcy分别是影响血浆内脂素水平的独立相关因素。结论脑梗死患者血浆内脂素水平显著升高,检测该指标对脑梗死的预防及病情监测有重要作用。
机构地区 沂源县人民医院
出处 《山东医药》 CAS 2012年第25期38-39,共2页 Shandong Medical Journal
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参考文献11

  • 1Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a protein se- creted by visceral fat that mimics the efects of insulin[ J ]. Science, 2005,307 ( 5708 ) :426 -430.
  • 2Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus[J]. J Clin Endocfinol Metab, 2006,91 (1) :295- 299.
  • 3秦宇,吕田,于红玖.内脂素与冠心病[J].国际心血管病杂志,2009,36(5):260-263. 被引量:11
  • 4杨媚,杨刚毅,李伶,李清明,阮华玲,阳皓,李钶,孙勤,唐毅,Gunther Boden.不同糖耐量个体血浆内脂素水平的变化[J].中华内分泌代谢杂志,2006,22(3):245-247. 被引量:76
  • 5van der Veer E, Nong Z, Onef C, et al. Pre-B-cell colony enhan- cing factor regulates NAD dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation [ J ]. Circ Res, 2005,97( 1 ) :25-34.
  • 6Zhong M, Tan HW, Gong HP, et al. Increased serum visfatin in patients with metabolic syndrome and carotid atherosclerosis [ J ]. Clinical Endocrinology, 2008,69(6) :878-884.
  • 7Bae SK, Kim SR, Kim JO, et al. Hypoxic induction of human vis- latin gene is directly mediated by hypoxia-inducible factor [ J ]. FEBS Lett, 2006,580 ( 17 ) :4105-4113.
  • 8Segawa K, Fukuhara A, Hosogai N, et al. Visfatin in adipocytes is upregulated by hypoxia through H IF1 alpha-dependent mechanism [J]. Biochem Biophys Res Commun, 2006,349(3) :875-882.
  • 9Doe C, Bentley R, Behm DJ, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities [ J ]. J Pharmacol Exp Ther, 2007,320( 1 ) :89-98.
  • 10Yamashita K, Kotani Y. Fasudil, a Rho kinase(ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons [ J ]. Brain Res, 2007,1154 ( 1 ) : 215- 224.

二级参考文献26

  • 1Samal B, Sun Y, Stearn G, et al. Cloning and characterization of the cDNA encoding a novel human pre B-cell colony-enhancing factor[J]. Mol Cell Biol, 1994, 14 (2):1431-1437.
  • 2Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin[J]. Science, 2005, 307(5708): 426-430.
  • 3Curat CA, Wegner V, Sengenes C, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin[J]. Diabetologia, 2006, 49(4) :744-747.
  • 4Ognjanovic S, Bao S, Yamamoto SY, et al. Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes [J]. J Mol Endoerinol, 2001, 26(2): 107-117.
  • 5Kitani T, Okuno S, Fujisawa H. Growth phase-depen-dent changes in the subcellular localization of pre-Bcell colony-enhancing factor[J]. FEBS Lett, 2003, 544(1/3): 74-78.
  • 6Hug G, Lodish HF. Visfatin:a new adipokine[J]. Science, 2005, 307(5708):366-367.
  • 7Bae SK, Kim SR, Kim JG, et al. Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1[J]. FEBSLett, 2006, 580(17): 4105-4113.
  • 8Segawa K, Fukuhara A, Hosogai N, et al. Visfatin in ad- ipocytes is upregulated by hypoxia through HIFlalpha-dependent mechanism[J]. Biochem Biophys Res Commun, 2006, 349(3): 875- 882.
  • 9Dahl TB, Yndestad A, Skjelland M, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis possible role in inflammation and plaque destabilization[J~. Circulation, 2007, 115(8) : 972-980.
  • 10Adya R, Tan BK, Chen J, et al. Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells:Its role in MMP-2/9 production and activation[J]. Diabetes Care, 2008, 31 (4):758-760.

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