趋化因子受体4在普通型骨肉瘤中的表达及意义

Expression and clinical implication of Chemokine receptor 4 in conventional osteosarcoma

目的探讨趋化因子受体4(chemokine receptor 4,CXCR4)在普通型骨肉瘤中的表达及其临床意义。方法应用免疫组织化学法检测38例普通型骨肉瘤患者肿瘤组织中CXCR4的表达水平,并对其与肿瘤病理学类型、性别和转移的关系进行统计学分析。结果 38例骨肉瘤组织中CXCR4阳性率为50.0%,不同性别和病理学类型的骨肉瘤组织中CXCR4阳性率无显著差异(P>0.05),而有、无转移发生的骨肉瘤组织中CXCR4阳性率分别为38.5%和75.0%,有显著性差异(P<0.05)。结论 CXCR4可作为预测普通型骨肉瘤转移的指标。

Objective To investigate the expression and clinical implication of chemokine receptor 4 in conventional os teosarcoma. Methods The expression of chemokine receptor 4 was detected by using immunohistochemistry in 38 cases of con ventional osteosarcoma, and its correlation with gender, histopathological types, metastasis was analyzed. Results The posi tive rate of chemokine receptor 4 in conventional osteosareomas was 50. 0%, and there were no significant differences in posi tive rate of chemokine receptor 4 between males and females, and between different histopathological types. There was signifi cant difference in chemokine receptor 4 positive rate between patients with metastasis and those without metastasis （38. 50% vs. 75.0 %, P〈0. 05）. Conclusion Chemokine receptor 4 might become a predictor of metastasis in conventional osteosarcoma.