阿托伐他汀联合氯砒格雷治疗不稳定型心绞痛的疗效观察

Observation of the curative effect of the atorvastatin combined whit clopidogrel treatment for unstable angina pectoris

目的探讨阿托伐他汀联合氯砒格雷治疗不稳定型心绞痛(UAP)的临床疗效。方法将158例UAP患者随机分为两组,每组79例,对照组在常规治疗的基础上加用阿托伐他汀治疗,观察组则在对照组的基础上加用氯砒格雷治疗,两组均于治疗前后测定血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,并测定超敏C反应蛋白(hs-CRP)。结果观察组的总有效率为97.47%,对照组为74.68%(P<0.05);两组治疗后的TG、TC、LDL-C、hs-CRP均较治疗前明显降低(P<0.05),而HDL-C较治疗前明显升高(P<0.05),观察组TG、HDL-C与对照组比较差异有统计学意义(P<0.05)。结论阿托伐他汀联合氯砒格雷治疗UAP疗效确切,安全,能降低血清hs-CRP水平和心血管事件的发生率。

Objective To investigate the clinical efficacy of atorvastatin combined with clopidogrel treatment for unstable angina pectoris （UAP）. Methods 158 patients with UAP were randomly divided into two groups, 79 cases in each group, the control group was treated by atorvastatin on the basis of routine treatment, and the observation group was treated by clopidogrel on the basis of the control group, two groups were determined before and after treatment of blood total cholesterol （TC）, three TG （TG）, high density lipoprotein cholesterol （HDL--C） and low density lipoprotein cholesterol （LDL--C） level, and measurement of high sensitivity C reactive protein （hs--CRP）. Results In the observation group, the total effective rate was 97.47%, the control group was 74.68% （P 〈 0.05）; the TC, TG, LDL--C of two groups were all significantly decreased more than before treatment, while HDL--C rose significantly, and the TG, HDL--C of the observation group were improved more obviously than the control group, there was different statistically significant （P 〈 0.01 or P 〈 0.05）. Conclusions The atorvastatin combined whir clopidogrel treatment for UAP can exact curative effect, which is safe, can decrease the levels of hs--CRP and the incidence of cardiovascular events.