期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

经冠状动脉注入替罗非班对急性心肌梗死患者PCI术后血流及近期预后的影响 被引量：10

下载PDF
导出
摘要 目的评价经冠状动脉注入替罗非班(血小板GPⅡb/Ⅲa受体拮抗剂)对急性心肌梗死(acute myocardial infarction,AMI)患者行经皮腔内冠状动脉成形术(percutaneous coronary intervention,PCI)术后血流及近期预后的影响。方法 AMI患者52例,续贯分为替罗非班组(n=26)和对照组(非替罗非班组,n=26)进行前瞻性研究,观察用药后罪犯相关血管心肌梗死溶栓治疗(thrombolysis in myocardial infarction,TIMI)血流分级情况,1周内主要心血管事件(MACE)、出血事件的发生率及心功能情况。结果替罗非班组术后罪犯相关血管TIMI血流明显优于对照组(P<0.05),1周内全因死亡、MACE发生率、出血事件发生率两组比较差异无统计学意义(P>0.05),术后1周替罗非班组心功能明显优于对照组,差异有统计学意义(P<0.05)。结论经冠状动脉内给予替罗非班可有效改善PCI术后血流情况,改善心功能,不增加出血发生率。
作者 何文凯 李明琰 陆东风 邢晓雯
机构地区 广州医学院第一附属医院心血管内科
出处 《广东医学》 CAS CSCD 北大核心 2012年第13期2010-2012,共3页 Guangdong Medical Journal
关键词 替罗非班 心肌梗死溶栓治疗血流 疗效
分类号 R654.2 [医药卫生—外科学]
  • 相关文献

参考文献8

  • 1SILBER S, ALBERTSSON P, AVILES F F, et al. Guidelines for percutaneous coronary interventions. The Task Force for Percuta- neous Coronary Interventions of the European Society of Cardiology [J]. Eur Heart J, 2005, 26(8) : 804 -847.
  • 2张成.替罗非班治疗急性冠脉综合征介入术后无复流的临床研究[J].实用心脑肺血管病杂志,2011,19(4):527-528. 被引量：11
  • 3YIP H K, CHEN M C, CHANG H W, et al. Angiographic mor- phologic features of infarct - related arteries and timely reperfusion in acute myocardial infarction : predictors of slow - flow and no - reflow phenomenon[ J]. Chest, 2002, 122 (4) : 1322 - 1332.
  • 4GIRI S, MITCHEL J F, HIRST J A, et al. Synergy between intra- coronary stenting and abciximab in improving angiographic and clinical outcomes of primary angioplasty in acute myocardial infarc- tion[J]. Am J Cardiol, 2000, 86(3) : 269 -274.
  • 5SEYDOUX C, GOY J J, DAVIES G. Platelet and neutrophil ima- ging techniques in the investigation of the response to thrombolytic therapy and the no- reflow phenomenon[ J ]. Am Heart J, 1993, 125(4) : 1142 -1147.
  • 6谢晓春,刘胜林,杨军珂,李元风,赵贵峰,胡丽华,白玉蓉,丁力平.替罗非班对急性心肌梗死急诊介入治疗后微血管功能不全和早期左心室重构的影响[J].中国循环杂志,2007,22(4):267-270. 被引量：13
  • 7BOLOGNESE L, FALSINI G, LIISTRO F, et al. Randomized comparison of upstream tirofiban versus downstream high bolus dose tirofiban or abciximab on tissue - level perfusion and troponiu release in high - risk acute coronary sy~dromes treated with percu- taneous coronary interventions : the EVEREST trial [ J ]. J Am Coll Cardiol. 2006, 47 (3) : 522 - 528.
  • 8WU T G, ZHAO Q, HUANG W G, et al. Effect of intracoronary tirofiban in patients undergoing percutaneous coronary intervention for acute coronary syndrome[ J]. Circ J, 2008, 72(10) : 1605 - 1609.

二级参考文献20

  • 1谢晓春,杨军珂,丁力平,梁明,白玉蓉,刘胜林,赵贵峰.卡托普利联合美托洛尔对急性心肌梗死晚期左心室重构的影响[J].中华老年心脑血管病杂志,2006,8(9):594-596. 被引量：5
  • 2Silber S, Albertsson P, Aviles FF, et al. Guidelines for Percutaneous Coronary Interventions. The task force for percutaneous coronary interventions of the European society of cardiology [ J ]. Eur Heart J, 2008, 26 (8): 804-847.
  • 3Kotani J, Nanto S, Mintz GS, et al. Plaque gruel ofatheromatous coronary lesion may contribute to the no - reflow phenomenon in patients with acute coronary syndrome [ J ]. Circulation, 2005, 106 (13) : 1672 - 1677.
  • 4Kunichika H, Ben - Yehuda O, Lafitte S. Effects of Glyeoprotein II b/III a Inhibition on Microvascular Flow After Coronary Reperfusion : A Quantitative Myocardial Contrast Echocardiography Study [ J ]. Journal of the America College of Cardiology, 2004, 43 : 276 - 283.
  • 5Warnhoitz Ascan, Ostad Mir Aboifazl, Heitzer Thomas. Effect of Tirofiban on Percutaneous Coronary Intervention - Induced Endothelial Dysfunction in Patients With Stable Coronary Artery Disease [ J ]. Am J Cardiol, 2005, 95: 20-23.
  • 6Valgimigli M, Percoco G, Barbieri D, et al. The Additive Value of Tiroflban Administered With the High - dose Bolus in the Prevention of Isehemic Complications During High - risk Coronary Angioplasty: the Advanced Trial [J]. J Am Coll Cardiol, 2006, 4 (1) : 14 -19.
  • 7Wu KC, Zerhouni EA, Judd RH, et al. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation, 1998,97:765-772.
  • 8The EPISTENT Investigators. Randomised placebo-controlled and balloon-angioplasty-controlled trim to assess safety of coronary stenting with use of platelet glycoprotein-lI b/IIIa blockade. Lancet, 1998, 352: 87 -92.
  • 9Rezkalla SH, Kloner RA. No-reflow phenomenon. Circulation ,2002,105 : 656-662.
  • 10Bolognese L, Neskovic AN, Parodi G, et al. Left ventricular remodeling following primary eorenary angioplasty : patterns of left ventrieular dilation and long-term prognostic implications. Cireulation, 2002, 106: 2351- 2357.

共引文献22

同被引文献83

  • 1丁晓隽,周旭晨,朱皓,李慧华.国产替罗非班对急性ST段抬高性心肌梗死患者急诊介入术后冠状动脉血流和心肌灌注影响的研究[J].中华临床医师杂志（电子版）,2011,5(8):2429-2431. 被引量：5
  • 2王云川,常学锋,刘国辉,陶贵周.SYNTAX评分对急性心肌梗死患者急诊PCI术后无复流现象的预测价值[J].中国老年学杂志,2014,34(1):39-42. 被引量：16
  • 3郑莺,刘建平.糖尿病致冠状动脉粥样硬化的机制[J].心脏杂志,2007,19(3):347-350. 被引量：23
  • 4Gibson CM,Ryan KA,Kelley M,et al. Methodologie drift in the assessment of TIMI grade 3 flow and its implica- tions with respect to the reporting of angiographie trim results[J]. Am Heart J,1999,137(6) :1179-1184.
  • 5Hoffman R, Haager P, Arning J, et al. Usefulness of myo- cardial blush grade early and late after primary coronary angioplasty for acute myocardial infarction in predicting left ventricular function[J]. Am J Cardiol, 2003,92 (9) : 1015-1019.
  • 6Razakir OA,Tan HC,Yip WL,et al. Predictors of bleeding complications and thrombocytopenia with the use of abciximab during percutaneous coronary intervention[J]. J Interv Cardiol, 2005,18 ( 1 ) : 33-37.
  • 7Turkmen S, Dogdu O, Tekin K, et al. The relationship be- tween neutrophil/lymphoeyte ratio and the TIMI flow grade in patients with STEMI undergoing primary PGI [J].Eur Rev Med Pharmaeol Sci, 2013, 17 (16):2185- 2189.
  • 8Safian RD. MASTER trial:In search of the optimal PCI approach to STEMI [J]. Catheter Cardiovase Interv, 2013,82(2) : 191-192.
  • 9Balghith MA. High bolus tirofiban vs abciximab in acute STEMI patients undergoing primary PCI-the tamip study [J]. Heart Views, 2012,13 (3) : 85-90.
  • 10Kurt IH, Demirkol S, Onal I, et al. Changes in BNP, hs- CRP and TIMI risk index with addition of tirofiban dur- lng prlmary percutaneous coronary intervention for acute STEMI:a prospective observational cohort study[J]. An- adolu Kardiyol Derg, 2012,12(2) : 107-114.

引证文献10

二级引证文献36

广东医学
2012年 第13期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部