丙泊酚对围手术期肺损伤的保护被引量：2

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摘要肺是体内唯一一个接受全部心输出量的器官，是全身静脉血的滤器，血内的有害物质容易阻留在肺；肺也是一个开放器官，经过各级支气管、气管与外界相通；同时肺泡巨噬细胞等炎症细胞释放出各种血管活性物质和炎症介质，直接损伤肺组织。围手术期间肺是严重损伤出现最早的器官。围手术期肺损伤的病变程度可以从表现为肺功能改变的亚临床性损伤到严重的急性肺损伤甚至急性呼吸窘迫综合征，

作者方舜黄巧冰

机构地区南方医科大学第一临床医学院南方医科大学基础医学院病理生理教研室

出处《广东医学》 CAS CSCD 北大核心 2012年第13期2021-2023,共3页 Guangdong Medical Journal

关键词急性肺损伤围手术期间丙泊酚急性呼吸窘迫综合征保护血管活性物质肺泡巨噬细胞炎症介质

分类号 R563 [医药卫生—呼吸系统]

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参考文献21

1詹美俊,姚尚龙,张诗海.异丙酚对肺缺血再灌注损伤大鼠肺上皮细胞凋亡的影响[J].中华麻醉学杂志,2007,27(6):558-561. 被引量：7
2咸云淑,姜春玲,郑利民,罗华,张锦芝,林影芯.丙泊酚对大鼠全肝缺血-再灌注后肺损伤的影响[J].临床麻醉学杂志,2010,26(5):430-432. 被引量：7
3QUADRI S M, SEGALL L, DE PERROT M, et al. Caspase inhi- bition improves isehemia - reperfusion injury after lung transplanta- tion[J]. Am J Transplant, 2005, 5(2) : 292 -299.
4梁义,单世民,徐凯,张敏.异丙酚对内毒素致大鼠急性肺损伤的保护作用及机制[J].中国现代医生,2009,47(16):33-35. 被引量：3
5VASILEIOU I, KALIMERIS K, NOMIKOS T, et al. Propofol pre- vents lung injury following intestinal ischemia - reperfusion [ J ]. J Surg Res, 2012, 172(1) : 146 -152.
6KAWAI T, TAKEUCHI O, FUJITA T, et al. Lipopolysaccharide stimulates the MyD88 - independent pathway and results in activa- tion of IFN - regulatory factor 3 and the expression of a subset of li- popolysaecharide- inducible genes[J]. J Immunol, 2001, 167(10) : 5887 -5894.
7JIANG Q, AKASHI S, MIYAKE K, et al. Lipopolysaccharide in- duces physical proximity between CD14 and Toll like receptor 4 (TLR4) prior to nuclear translocation of NF - KB [ J ]. J Immu- nol, 2000, 165(7) : 3541 -3544.
8TOGBE D, SCHNYDER CANADRIAN S, SCHNYDER B, et al. TLR4 gene dosage contributes to endotoxin induced acute respirato- ry inflammation [ J ]. J Leukocyte Biol, 2006, 80 (3) : 451 - 457.
9马铃,李万冬,陈卫民.异丙酚对脂多糖诱导的急性肺损伤大鼠肺组织Toll样受体表达的影响[J].中国医科大学学报,2009,38(4):261-264. 被引量：4
10JAWAN B, KAO Y H, GOTO S, et al. Propofol pretreatment at- tenuates LPS - induced granulocyte - macrophage colony - stimula- ting factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF - kappaB translocation [ J ]. Toxicol Appl Pharmacol, 2008, 229 (3) : 362 - 373.

二级参考文献67

1阚彤,杨甲梅,童颖.肝切除术后急性肺损伤和呼吸窘迫综合征的诊治[J].中华肝胆外科杂志,2005,11(2):130-131. 被引量：6
2张银中,叶铁虎,赵丽云,任洪智,黄宇光.白细胞介素-6、白细胞介素-10及异丙酚对中性粒细胞内caspase-3活性的影响[J].中华麻醉学杂志,2005,25(2):143-144. 被引量：4
3LászlóVáli,Gabriella Taba,KláraSzentmihályi,HedvigFébel,TímeaKurucz,Zsolt Pallai,PéterKupcsulik,AnnaBlázovics.Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion[J].World Journal of Gastroenterology,2006,12(7):1086-1091. 被引量：6
4王建春,姜鹏,谢艳萍,钱桂生.急性肺损伤大鼠肺组织NF-κB表达的研究[J].中国现代医学杂志,2006,16(16):2448-2452. 被引量：17
5邓朝胜,王辰,庞宝森,杨媛华,杜敏捷,齐曼,翁心植.中性粒细胞在肺血栓栓塞症犬肺缺血-再灌注损伤中的作用[J].中华结核和呼吸杂志,2006,29(9):603-606. 被引量：12
6Witzenbichler B, Westermann D, Knueppel S,et al. Protective role of angiopoietin- 1 in endotoxic shock[J]. Circulation, 2005, 111 : 97-105.
7Tsuji G,Minhaz MU,Shioya S,et al. The important of polymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production and lung injury: vivo observation in rat lung [J]. Lung, 1998, 176: 1-13.
8Haddad IY,Pataki G,Hu P. Quantitation of nitrotyrosine levels in lung section of patients and animals with acute lung injury[J]. J Clin Invest, 1994,94 : 2407.
9Wizemann TM, Garndner CR, Laskin JD. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia[J]. J Leukoc Biol, 1994,56 ( 2 ) : 759-768.
10Berthiaume Y, Lesur O, Dagenais A. Treatment of adults respiratory distress syndrome : Plea for rescue therapy of the alveolar epithelium [ J]. Thorax, 1999,54 : 150 - 160.