酮咯酸氨丁三醇用于预防深静脉穿刺置管静脉血栓发生及其护理被引量：2

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摘要目的探讨酮咯酸氨丁三醇对重型颅脑损伤患者行深静脉穿刺置管静脉血栓发生的预防作用和护理体会。方法对重型颅脑损伤患者分别单纯行深静脉穿刺置管(对照组)和深静脉穿刺置管加用酮咯酸氨丁三醇(观察组),配合相关护理措施,采用放射免疫分析法和发射底物分析法测定在行深静脉穿刺前及深静脉穿刺后1h及1、2、3 d 5个不同时间段镇痛血浆β-内啡肽(β-EP)、血栓素A2(TXA2)、6-酮-前列腺素F1α(6-keto-PGF1α)、血浆组织型纤溶酶原激活物(tPA)和血纤溶酶原激活抑制物(PAI)含量的变化。结果对照组置管前β-EP、TXA2和PAI随时间进展呈递增趋势,6-keto-PGF1α和tPA则呈递减趋势;观察组则与之相反。结论酮咯酸氨丁三醇通过减少疼痛应激,触发纤溶系统和抑制血小板聚集,稳定正常人体内凝血系统与抗凝血系统的动态平衡,同时配合优质的护理,可减少静脉血栓的发生。

作者朱丽云段善娥潘玉群

机构地区暨南大学附属第一医院急诊科暨南大学附属第一医院麻醉科广东省人民医院

出处《广东医学》 CAS CSCD 北大核心 2012年第14期2190-2193,共4页 Guangdong Medical Journal

关键词酮咯酸氨丁三醇注射液深静脉穿刺置管静脉血栓护理体会

分类号 R472.9 [医药卫生—护理学]

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