某院二代精神科药物在门诊使用情况的调查分析

Investigation of the second generation antipsychotics use in the general outpatient department in a hospital

目的了解某院精神科门诊处方中二代精神科药物使用特点、医生用药习惯、药物剂量是否合理。方法从某医院精神科门诊2011年7-10月的处方中,随机抽取299张普通处方,采用国际通行使用的药品的限定日剂量(DDD)、用药频度(DDDs)、限定日均费用(DDDc)和药物利用指数(Index)、用药时间、联合用药方面进行监测。结果精神科药物平均药物使用指数均在1.0左右(0.95～2.2);用药时间2周以上的超过80%,使用1种药物的处方比例为49%,使用2种或2种以上药物的处方比例为36.7%。结论大部分精神科药物无滥用现象,但存在药物使用时间相对较长、联合用药明显、个别药物使用量大的情况,亟待进一步规范管理。

Objective To investigate the use of the second generation antipsychotics and the rationality of the general outpatient prescription in a hospital. Methods In the present work,299 outpatient prescriptions from a mental hospital were chose from July to October in 2011. The parameters of drug use were monitored, such as DDD, DDDs, DDDc, average drug utilization index,medication time and combination therapy. Results The average drug utilization index was around 1.0 for each prescription,the range from 0. 95 to 2. 2 ,over 80% prescriptions bear medication time of more than 2 weeks, and the percentage of mono-therapy was 49% , while 36. 7% in the combination therapy. Conclu- sion For most prescriptions, antipsychotics abuse has not been observed, but some aspects in the drug use are to be regulated, including comparatively long medication time, some obvious combination therapy and extensive use of certain antipsychotics.