结肠癌组织中Survivin、基质金属蛋白酶-9和血管内皮生长因子的表达及临床意义

Expression and clinical significance of Survivin, MMP-9 and VEGF in colonic carcinoma tissue

目的探讨Survivin、基质金属蛋白酶-9（MMP-9）和血管内皮生长因子（VEGF）在结肠癌组织中的表达及其与肿瘤进展的关系。方法采用免疫组化SP法检测60例结肠癌组织中Survivin、MMP．9和VEGF表达情况，并以25例正常结肠组织作为对照。结果结肠癌组织中Survivin、MMP-9和VEGF表达显著高于正常结肠组织（P〈0．05）。结肠癌患者中Ⅲ-Ⅳ期、淋巴结转移患者的Survivin、MMP-9和VEGF阳性表达率分别高于Ⅰ-Ⅱ期和无淋巴结转移患者（P〈0．05）。结论结肠癌组织中Survivin、MMP-9和VEGF的表达水平明显升高。在结肠癌的浸润转移中起到了重要的作用，可作为反映结肠癌进展的生物学指标。

Objective To investigate the expression and clinical significance of Survivin, matrix metalloproteinase（MMP-9） and vascular endothelial growth factor（VEGF） in colonic carcinoma tissue and its relationship with tumor progress. Methods The expression levels of Survivin, MMP-9 and VEGF were measured by immunohistochemistry in the resected specimens from 60 patients with colonic carcinoma and 25 controls. Results The positive rates of Survivin, MMP-9 and VEGF were significantly higher in the co- lonic carcinoma patients than those in ＇controls （P 〈 0. 05）. The positive rates of Survivin, MMP-9 and VEGF in Ⅲ-Ⅳ stage were significantly higher than those of patients in Ⅰ-Ⅱ stage tumor （P 〈 O. 05 ）. The positive rates of Survivin, MMP-9 and VEGF in lymph node metastasis tumor were significantly higher than those of patients in non metastasis tumor （P 〈 0. 05）. Conclusions Survivin, MMP-9 and VEGF expression in colonic carcinoma increases markedly and play an important role in the progression of colonic carcinoma.