生存素蛋白在喉癌组织中的表达和意义的meta分析

Meta-analysis of the expression and significance of survivin in laryngeal carcinoma

目的研究生存素（Survivin）蛋白在喉癌组织中的表达及意义。方法以“Survivin”和“喉癌”为关键词在万方数据库、中国学术期刊数据库、中文科技期刊数据库上联合检索2000年至20t1年国内专业期刊发表的关于Survivin在喉癌组织中表达的独立病例对照研究的论文，并对文献进行异质性检验，以病例组与对照组比值比（OR值）为效应指标，然后应用Meta分析软件RevMan4．3对各研究原始数据进行统计处理，并计算合并OR值及95％可信区间（95％C1），同时绘制Meta分析森林图。结果有12篇文献纳入Meta分析，累计喉癌患者605例，对照组373例。喉癌组与正常组织组OR值为26．38，95％c，为（14．97，46．47）。喉癌组与癌旁组织组OR值为4．19，95％CI为（2．50，7．03）。Survivin表达与喉癌临床分期（P〈0．01）、病理学分级（P〈0．01）、淋巴结转移（P〈0．05）之间存在明显相关，而与喉癌分型（P〉0．05）无明显关联。结论对相关文献研究结果的Meta分析显示，Survivin的高表达可能在喉癌的发生、发展、转移中起重要作用，其同时可成为喉癌的恶性程度与预后的指标。

Objective To investigate the expression and significance of survivin in laryngeal car- cinoma tissue. Methods Documents published in China from 2000 to 2011 were retrieved through CNKI, VIP, and wanfang database. The inclusive criteria of studies must be the case-control ones associat- ed with survivin and laryngeal neoplasms. Taking into account the possibilities of heterogeneity of the studies, a statistical test for heterogeneity was performed. The Meta-analysis was applied with RevMan 4.3 software. Results Twelve of case-control studies were selected for this Meta-analysis with a total of 605 laryngeal carcinoma cases and 372 controls included. The pooled odds ratio between laryngeal carcinoma cases and normal membrana mucosa laryngis cases was 26.38, and 95% CI was （ 14.97,46. 47 ）. The pooled odds ratio between laryngeal carcinoma cases and peficaneerous tissues cases was 4. 19, and 95% C/was （2.50,7.03）. The expression of Survivin was correlated with clinical stages （P 〈 0. 01）,patho- logical differentiation （P 〈 0. 01 ） and lymph node metastasis （P 〈 0. 05） ,but was not correlated with ana- tomical regions （P 〉 0. 05 ）. Conclusions Survivin may play an important role in the carcinogenesis, progress and metastasis of laryngeal carcinoma, which may be valuable for the diagnosis and prognosis.