摘要
脂联素作为重要的脂肪因子,在血浆中有低、中、高分子量多聚体3种类型,其中高分子量(HMW)脂联素是脂联素主要的活性形式。研究发现,其降低与胰岛素抵抗密切相关。非酒精性脂肪性肝病(NAFLD)作为代谢综合征的表现之一,发病率也逐年攀升,合并NAFLD的患者HMW脂联素水平下降,胰岛素抵抗程度加重,主要与肝脏炎性反应加重、胰岛素的敏感性下降、脂代谢异常有关。调节脂联素水平对NAFLD的防治具有一定临床意义。
As an important adipocytokine, adiponectin has three multimers isoforms in the plasma in- cluding low molecular weight trimer, medium molecular weight hexamer and high molecular weight (HMW) muhimers, among which the latter is the most active complex. Evidences show that decreased HMW adiponce-tin is strongly associated with insulin resistance. The prevalence of nonalcoholic fatty liver disease (NAFLD) , one of the components of metabolic syndrome, is increasing. The decreased serum level of HMW adiponectin and insulin resistance was observed in patients with NAFLD, which involved in aggravated inflam-mation, lower insulin sensitivity and lipid metabolism dysfunction in the liver. Regulate the concentration of HMW adiponectin is of great importance for the prevention of NAFLD.
出处
《国际内分泌代谢杂志》
北大核心
2012年第4期273-275,共3页
International Journal of Endocrinology and Metabolism
关键词
脂联素
高分子量多聚体
非酒精性脂肪性肝病
胰岛素抵抗
Adiponectin
High molecular weight multimer complex
Non-alcoholic fatty liver dis-ease
Insulin resistance