高分子量脂联素与非酒精性脂肪性肝病

High molecular weight adiponectin and non-alcoholic fatty fiver disease

脂联素作为重要的脂肪因子，在血浆中有低、中、高分子量多聚体3种类型，其中高分子量（HMW）脂联素是脂联素主要的活性形式。研究发现，其降低与胰岛素抵抗密切相关。非酒精性脂肪性肝病（NAFLD）作为代谢综合征的表现之一，发病率也逐年攀升，合并NAFLD的患者HMW脂联素水平下降，胰岛素抵抗程度加重，主要与肝脏炎性反应加重、胰岛素的敏感性下降、脂代谢异常有关。调节脂联素水平对NAFLD的防治具有一定临床意义。

As an important adipocytokine, adiponectin has three multimers isoforms in the plasma in- cluding low molecular weight trimer, medium molecular weight hexamer and high molecular weight （HMW） muhimers, among which the latter is the most active complex. Evidences show that decreased HMW adiponce-tin is strongly associated with insulin resistance. The prevalence of nonalcoholic fatty liver disease （NAFLD） , one of the components of metabolic syndrome, is increasing. The decreased serum level of HMW adiponectin and insulin resistance was observed in patients with NAFLD, which involved in aggravated inflam-mation, lower insulin sensitivity and lipid metabolism dysfunction in the liver. Regulate the concentration of HMW adiponectin is of great importance for the prevention of NAFLD.