汽车尾气颗粒物的遗传毒性及其毒作用机理的研究

The Effect of Pellet of Automotive Exhaust Gas on Hereditary Toxicity and Mechanism

为了探讨汽车尾气颗粒物的遗传毒性及其毒作用机理 ,给小鼠腹腔注射柴油机尾气颗粒物有机提取物后 ,对其进行了骨髓微核实验及红细胞超氧化物歧化酶 (SOD)活性和肝组织过氧化脂质(LPO)水平影响的研究。结果表明 ,染毒组小鼠微核阳性率与对照组相比明显升高 ,有显著性差异 (P<0 .0 1 ) ,且呈明显的剂量反应关系 ;染毒组小鼠 SOD活性下降及 LPO水平升高与对照组比有显著性差异 (P<0 .0 1 ) ,且呈明显的剂量反应关系 。

To finding hereditary toxicity and mechanism of pellet of automotive exhaust gas,after abdominal injection examine micronucleus in sternum marrow and SOD in red cells and LPO in liver in mice.Result shows that comparing the positive rare of the exposure groups with that of the control obviously increase in frequency of micronucleus,significant difference(\%P<0\^01\%) and the dose\|effect relationship exist;SOD activity decreasing and LPO level increasing have significant difference(\%P<0\^01\%) and the dose\|effect relationship.From above results it seems that the pellet of automotive exhaust gas have definite toxicity.