神经节苷酯对脑瘫患儿运动与智力发育的作用

目的 观察神经节苷酯治疗对脑性瘫痪患儿运动与智力的作用.方法 60例脑性瘫痪患儿按就诊时间随机分为观察组（综合康复治疗＋神经节苷酯）和对照组（综合康复治疗）两组,连续治疗3个月.治疗前后分别用粗大运动功能量表评估和Gesell智力测试.结果 治疗结束后观察组总有效率（93.3%）高于对照组（80.0%）,差异有统计学意义（P〈0.01）;观察组适应性项中发育商得分高于对照组,差异有统计学意义（P〈0.01）.结论 神经节苷酯能显著改善脑性瘫痪患儿的运动与智力发育,对脑性瘫痪有较好的治疗效果.

Objective To study the effects of ganglioside on development of movement and intelligence in children with cerebral palsy. Methods 60 children with cerebral palsy were randomly divided into two groups, the observation group （ comprehensive rehabilitation treatment＋ganglioside ） and the control group （ comprehensive rehabilitation therapy ） treatment for 3 consecutive months, gross motor function measure （GMFM） was assessed and Intelligence was tested with Gesell before and after treatment. Results After treatment, the total efficiency in the observation group （ 93.3% ） was higher than the control group （ 80.0% ） （ P〈0.01 ） , Scale assessment of GMFM and the Gesell intelligence test adaptive developmental quotient scores of the observation group higher than the control group （ P〈0.01 ） . Conclusions Ganglioside significantly improves the movement and mental development of children with cerebral palsy, and has a better therapeutic effect on cerebral palsy.