闪光刺激在癫痫病人脑内电极的生理光驱动及病理光效应研究

Photic stimulation with physiological light driving intracranial electrodes in epilepsy patients and its pathological photo-effect

目的报告1例癫痫病人脑内电极对闪光刺激的反应。方法 1例部分性难治性癫痫病人在术前评估时利用立体定向技术,在枕-颞叶脑组织内不同部位置入电极,病人处于睁眼或闭眼状态,使用1-40Hz频率的光源刺激。结果出现明显生理性光驱动的电极接触点全部处于枕叶内侧面,靠近距状裂,但不同的电极接触点由于位于距状裂上下及距离其远近不同,出现生理光驱动的效果不同,未发现病理性光效应。结论通过癫痫病人脑内电极的置入,特别是在枕叶内侧面置入脑内电极,可以得到确切的关于视觉系统的生理信息。

Objective To report the response of an epilepsy patient to photic stimulation of intracranial electrodes.Methods A patient with refractory epilepsy was assessed with SEEG before operation.Electrodes were implanted into different sites of occipital-temporal lobes.The opened or closed eyes of the patient were stimulated with light source at the frequency of 1-40Hz.Results All the significant contacts of physiological light–driven electrodes,located in the medial occipital lobe,were close to the calcarine fissure.The photo-effect was different at different contacts of intracranial electrodes due to different distances to the calcarine fissure.No pathological photo-effect was observed.Conclusion Much precise physiological information on the physiological visual system of epilepsy patients can be obtained by implanting electrodes into their brain,especially into the medial occipital lobe.