摘要
目的 :消除异丙酚诱导时心血管抑制作用 ,探讨一种较为安全、合理的麻醉诱剂药物配伍。方法 :随机选择 2 0例ASAI～Ⅱ级、非心脏手术的全麻患者。采用氯胺酮 (1mg/kg)、异丙酚 (1.5～ 2 .0mg/kg)、芬太尼 (4μg/kg)、琥珀胆碱 (2 .0mg/kg)诱导 ,行气管插管 ,观察其心血管反应。结果 :麻醉诱导时、气管插管即刻、气管插管后 1、2、3min ,收缩压 (SBP)、舒张压 (DBP)、心率 (HR)、平均动脉压 (MAP)均无明显变化 (P <0 .0 5 )。结论 :将小剂量的氯胺酮和芬太尼与异丙酚联合应用 ,既能有效地抑制气管插管时的心血管副反应 。
Objective:To eliminate cardiovascular inhibition of propofol induction,searching for a safer and more reasonable drug combination of intravenous induction.Methods:Twenty patients(ASA I～Ⅱ) were chosen randomly.Patients undergoing cardiac surgery were exclude. Medication of induction: Ketamine 1 mg/kg,Propofol 1.5～2.0 mg/kg,Fentanyl 4 μg/kg,Scoline 2.0 mg/kg.During intubation,cardiovascular effects were observed.Results:The changes of SBP,DBP,HR,MAP at five period (Induction,intubation,the 1th,2th,3th minute after intubation) were nosignificant.Conclusion:Drug combination of little dose of Ketamine,Propofol, and Fentanyl can not only inhibit cardiovascular side effect significantly during intubation,but also decrease cardiovascular inhibition of Propofol.
