同型半胱氨酸、D-二聚体、超敏C-反应蛋白和纤维蛋白原与急性脑梗死患者关系的研究

Study on the relationship between homocysteine,d-dimer,high-sensibility C-reactive protein,fibrinogen and patients with acute cerebral infarction

目的研究急性脑梗死(ACI)患者血浆同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)、D-二聚体(DD)及纤维蛋白原(Fg)浓度水平的变化。方法用全自动生化分析仪BECKMANLX-20测定244例ACI患者(ACI组)、102名健康人(对照组)空腹血浆Hcy、DD、hs-CRP和Fg的浓度水平。结果 ACI患者血浆Hcy、DD、hs-CRP和Fg的浓度均显著高于对照组(P均<0.01)。结论血浆Hcy、DD、hs-CRP、Fg浓度水平与ACI的发生、发展密切相关,联合检测上述四项指标对ACI的预防、治疗和预后均有重要临床意义。

Objective To study concentration-level changes of homocysteine（Hcy）,high-sensibility C-reactive protein（hs-CRP）,D-Dimer（DD）,fibrinogen（Fg） in patients with acute cerebral infarction.Methods Concentration levels of fasting plasma Hcy,DD,hs-CRP as well as Fg from 244 patients（ACI） and 102 healthy people（control group） were determined by BECKMAN LX-20 automatic biochemical analyzer.Results The concentrations of Hcy,DD,hs-CRP and Fg in ACI patients were significantly higher than those in the control group respectively（P 0.01）.Conclusion Concentration levels of serum Hcy,DD,hs-CRP and Fg are closely related to the occurrence and development of ACI.Joint detection of the four indicators mentioned above has important clinical significance on prevention,treatment,and prognosis.