血清学与^(13)C-尿素呼吸试验检测反复腹痛儿童Hp感染比较

Study Hp infection in children with recurrent abdominal pain by serology and^(13) C- urea breath test

目的探讨血清学及~Ｃ尿素呼吸试验（^（１３）Ｃ－ ｕｒｅａ ｂｒｅａｔｈ ｔｅｓｔ，^（１３）Ｃ－ ＵＢＴ）在检测小儿反复腹痛（ｒｅｃｕｒｒｅｎｔ ａｂ－ｄｏｍｉｎａｌｐａｉｎ， ＲＡＰ）幽门螺杆菌（Ｈｐ）感染中的应用及ＲＡＰ与 Ｈｐ的关系。方法采用^（１３）Ｃ－ＵＢＴ及血清ＥＬＩＳＡ法检测抗Ｈｐ－ＩｇＧ。结果 ２００例经^（１３）Ｃ－ ＵＢＴ检测有 ５８例检出 Ｈｐ感染，检出率 ２９．０％；血清抗 Ｈｐ－ＩｇＧ测定阳性 １１１例，阳性率５５．５％；其中，２～，５～，１０～ １４岁 ３组患儿 Ｈｐ^（１３）Ｃ－ ＵＢＴ及 Ｈｐ－ ＩｇＧ检出率分别为 ２９．４％（１５／５１），２９．５％（３６／１２２），２５．９％（７／２７）；３７．３％（１９／５１），５９％（７２／１２２，７４％（２０／２７），３组间^（１３）Ｃ－ＵＢＴ结果差异无显著性（Ｐ＞０．０５），而Ｈｐ－ＩｇＧ结果差异有显著性（Ｐ＜０．０５）。结论①小儿反复腹痛与Ｈｐ感染密切相关；②抗Ｈｐ－ＩｇＧ的血清学检测阳性率明显高于^（１３）Ｃ－ＵＢＴ的检出率，Ｈｐ感染率随年龄增长而增加，但现症感染与年龄无关；③^（１３）Ｃ－ＵＢＴ检测Ｈｐ操作简单，安全，无痛苦且准确性高，为检测Ｈｐ现症感?

Objective To study the use of serology and^(13)C - UBT in detcecting HP infection in children with recurrent abdominal pain(RAP). Methods ^(13)C - UBT and serum Hp - IgG test were used. Results Among 200 patients, there were 58 cases with positive Hp by ^(13)C - UBT, with a positive rate of 29%; while the positive rate was 55 .5% (111/200) by Hp - IgG, significantly higher than the former. The positive rate was 29.4%, 29.5%, 25.9% and 37.3%, 59%, 74% respectively by ^(13)C - UBT and Hp - IgG in three groups of 2 ～, 5 ～, 10 ～ 14 years of age. There were no statically significances between the results of ^(13)C - UBT, but there were between results of Hp - IgG(P < 0. 05). Conclusion ①There is a close relationship between RAP and Hp infection. ②The sensitivity of Hp- IgG is higher than that of^(13)C - UBT. The infection rate grows with age, but present infection dose not relate to age. ③^(13)C - UBT is simple, safe, accurate, and effective way to detect Hp present infection.