Alzheimer型痴呆的中医证型研究

Research on TCM Pattern Identification in Dementia of the Alzheimer Type

为研究不同病情程度的Alzheimer型痴呆 (DAT)中医证型的分布规律与特征 ,将 1 3 9例DAT患者按照自拟标准 (以专项认知能力变化为主 ,结合MMSE计分及日常生活能力变化 )分为轻、中、重 3级 ,中医辨证分为心血不足、肾精虚衰等 6个主型及痰浊内蒙、瘀阻脑窍、火扰神明 3个兼型。结果表明 :DAT的病情轻重与不同中医证型直接相关 ,以一脏病变为主或多脏受累与其病情严重程度呈正相关 ,有无痰、瘀、火病邪相兼 ,既是促进病情转化的重要因素 ,亦直接影响DAT的病情严重程度。

HT6SS] In order to investigate the distribution regularity and feature of pattern identification in Chinese medicine in dementia of Alzheimer type (DAT)in the different severity,139 DAT cases were divided into the mild,moderate and severe grades upon the self drawn standard(changes in the special cognitive ability,together with changes in MMSE scores and daily life)and were identified into six major patterns of insufficiency in the heart blood,and deficiency and decline of kidney essence,and three annexed patterns of internal accumulation of phlegm turbidity,obstruction of stagnation in the brain,fire disturbance in the mind.The results showed that the severity in DAT condition was related directly to different patterns in Chinese medicine,and the pathological change in one organ or involvement of several organs was in positive correlation with severity of its pathological condition,and that the combination of phlegm,stagnation and fire was an important factor to promote the change in the pathological condition and also directly influenced the severity of DAT condition. [HT6ZY]