川崎病合并冠脉扩张危险因素分析

Analysis the Risk Factors of Kawasaki Disease Complicated with Coronary Artery Lesion

目的:分析川崎病(KD)患儿出现冠状动脉扩张(CAL)的危险因素。方法:回顾性分析2007年～2011年我院86例住院KD患儿临床资料,对CAL组(n=18)和无冠状动脉扩张组(nCAL组,n=66)的一般资料、临床表现、实验室检查三类18项指标进行组间比较及Logistic回归分析。结果:(1)热程>10天、杨梅舌、血沉>100mm/h、C-反应蛋白(CRP)>100mg/L等4项指标两组间差异有统计学意义(P<0.05);(2)热程>10天(X1)的OR值为7.500(95%CI=1.023～54.996,P<0.05),KD发生CAL的危险因素主效应模型是logit(P)=β0(-0.693)+2.015X1(χ2=7.500,P<0.05)。结论:杨梅舌、血沉>100mm/h、CRP>100mg/L是KD患儿发生CAL的危险因素,热程>10天是KD患儿发生CAL的高危因素。

Objective: To investigate the risk factors of coronary artery lesion (CAL) caused by Kawasaki disease. Method: We retrospectively reviewed the clinical records of 86 patients with Kawasaki disease admitted to our department from 2007 to 2011, risk factors including general information,clinical manifestation and laboratory parameters total 18 factors were contrast between with CAL(n=18) and without coronary artery lesion patients(n=66) by case-control study and logistic regression analysis. Results: There were significant differences between patients with and without coronary artery involvement in the duration of fever, bayberry tongue, ESR and CRP. The results of logistic regression analysis indicated that the odds ratio of fever lasting over 10 days(X1) was 7.500(95% CI=1.023～54.996,P<0.05). The logistic regress equation of CAL risk factors was logit(P)=β0(-0.693)+2.015X1(χ2=7.500,P<0.05). Conclusion: Bayberry tongue, ESR>100 mm/h and CRP>100 mg/L are risk factors, long-lasting fever (>10d) is the high-risk factors of CAL in Kawasaki disease.