反复自然流产与白细胞介素关系的研究

Relationship between recurrent spontaneous abortion and interleukin.

目的 探讨反复自然流产患者血清白细胞介素的变化。方法 采用酶联免疫吸附法检测 5 6例反复自然流产妇女血清中IL - 6、IL - 8、IL - 10的水平。流产患者分为两组 :早期流产和晚期流产。选择正常早孕妇女及非孕妇女各 2 0例作对照。结果 反复自然流产患者血清IL - 6、IL - 8含量明显高于对照组 (P <0 0 1) ,早期流产组升高明显。IL - 6与IL - 8之间呈正相关 (r =0 78,P <0 0 1) ,与IL - 10呈负相关 (r =- 0 5 4,P<0 0 5 )。流产患者血清中IL - 10的水平降低。

Objective To investigate the changes of serum interleukin in patients with recurrent spontaneous abortion(RSA).Methods Serum IL-6,IL-8,IL-10 were measured by enzyme-linked immunosorbant assay(ELISA) in 56 RSA,which were randomly divided into two groups:early RSA and late RSA.20 normal pregnancy and 20 nonpregnant women were as control groups.Results The serum IL-6,IL-8 in RSA group was obviously higher than that in normal control groups(P<0 01);IL-6 in RSA positively correlated with IL-8(P<0 05),and negatively correlated with IL-10(P<0 05);the IL-10 in RSA was markedly lower than that in control groups(P<0 01).Conclusion Changes of IL-6,IL-8,IL-10 in pregnant women is related with RSA.