妊娠期高血压疾病相关危险因素分析研究

目的探讨妊娠期高血压疾病(HDCP)发病的危险因素,为降低HDCP的发生提供切实可行的科学依据。方法采用1:1配对病例对照研究,收集病例组和对照组各100例,通过问卷调查的方式收集数据。应用条件Logistic回归模型进行多因素分析。临床生化指标与病情程度关系应用?2分析。结果⑴孕前BMI、年龄、职业、流产次数、高血压家族史、生活事件、状态-特质焦虑等项得分,与HDCP的危险因素有统计学意义(P<0.05)。⑵孕妇年龄、文化水平和家庭月收入与HDCP的发生存在剂量-效应关系。⑶总蛋白、白蛋白及血红蛋白值越低,HDCP病情越严重(P<0.05)。结论妊娠期高血压疾病的发生是多因素的结果,其中高龄产妇、孕前BMI、职业(农民工人)、高血压家族史、生活事件焦虑得分高、低白蛋白和低血红蛋白为主要危险因素;文化水平高、家庭月收入高和规律定期产检为HDCP的保护因素。

Objective To explore influencing factors of Hypertensive disorders complicating pregnancy （HDCP）, The objective of our research is provide practical scientific basis for decrease the risk of theHDCP. Methods The 1：1 matched case-control study of 100 pairs was carried out. All of the objects were investigated in uniform questionnaire about suspected influencing factors. We analyzed the data by conditional logistic-regression, Multivariate analysis was used for the statistical significant variables. Clinical biochemical indicators and the degree of disease was used the ANOVA analysis. Results 1.BMI before pregnancy, age, occupation, miscarriage, hypertension family history, total score of Life events scale, total score of STAI, differences was statistically significant （P〈0.05）. 2. These are dose response relationship between expectant mother of age, education level, family monthly income and HDCP. 3. TP, ALB, HBG count lower the value, the more serious condition. Conclusion The occurrence of HDCP was come from multiple factors. The main risk factors of HDCP include BMI, pregnancy age, occupation （peasant and worker）, hypertension family history, total score of case of LES-STAI, lower the value of ALB and HBG; Higher education level, higher family income, regular inspection of pregnancy were the protection of the HDCP factors.