摘要
The 7 (phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N dimethylsilylurea) using HBr 4 methylpyridine as catalyst. The effects of catal yst amount, reaction temperature and time were examined. Under optimum reaction condi tions product in 94% yield was obtained. The product has been characterized by IR and MS.
The 7 (phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N dimethylsilylurea) using HBr 4 methylpyridine as catalyst. The effects of catal yst amount, reaction temperature and time were examined. Under optimum reaction condi tions product in 94% yield was obtained. The product has been characterized by IR and MS.
出处
《应用化学》
CAS
CSCD
北大核心
2000年第3期346-348,共3页
Chinese Journal of Applied Chemistry
基金
河北省科委资助! (972 130 5 2 D)
关键词
头孢G酸
青霉素亚砜
催化扩环
制备
phenylacetamido deacetoxycephalosporin acid,penicillin G sulfoxide,protective silylation,catalytic ring expansion,preparation
