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蛇毒对止血系统的作用及临床应用

Effects of Snake Venoms on the Haemostatic System and Clinical Applications
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摘要 目前已知的3 000多种蛇中大约600种是有毒的。蛇毒几乎对每种动物的生理过程都能产生影响,例如神经毒素能阻断神经肌肉接头;细胞毒素和磷脂酶可引起肌肉坏死;眼镜蛇毒因子能抑制补体的活性及凝血系统中各种蛋白酶的作用。本文综述蛇毒对凝血系统、纤溶系统、微血管系统及血小板的影响,并介绍其在出血与血栓性疾病诊治中的应用。
出处 《血栓与止血学》 2012年第4期188-191,共4页 Chinese Journal of Thrombosis and Hemostasis
基金 首都医学发展科研基金(2005-1024)
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  • 1NICOLASE GAF,ROSING J. Activation of factor V by venom protea- ses[J]. Tox Rev,2006,25:217-234.
  • 2MIZUNO H, FUJIMOTO Z, ATODA H, et al. Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X [ J ]. Proc Natl Acad Sci USA,2001,98:7230-7234.
  • 3LEONARDI A, FOX JW,TRAMPU- S BA, et al. Two coagulation fac- tor X activators from Vipera a. ammodytes venom with potentiaho treat patients with dysfunctional factors IXa or VIIa [ J ]. Toxicon,2008,52 : 628-637.
  • 4VENKATESWARLU D, KRISHNASWAMY S, DARDEN TA, eta|. Threedimensional solution structure of tropidechis carinatus venom ex- tract trocarin: a structural homologue of Xa and prothrombin activator [J]. J Mol Model (Online),2002,8:302-313.
  • 5KINI, RM. The intriguing world of prothrombin activators from snake venom [ J .]. Toxicon ,2005,45 : 1133-1145.
  • 6VILCA- QUISPE A, PONCE- SOTO LA, WINCK FV, et al. Isolationand characterization of a new serine protease with thrombin-like activ- ity (TLBm) from the venom of the snake Bothrops marajoensis[ J l. Toxicon,2010,55:745-753.
  • 7CASTRO HC,ZINGAIL RB, ALBUQUERQUE MG, et al. Snake ven- om thrombin-like enzymes: from reptilase to now cell[ J ]. Mol. Life Sci ,2004,61 : 843-856.
  • 8MORITA T. Use of snake venom inhibitors in studies of the function and tertiary structure of coagulation factors [ J . Int J Hematol, 2004, 79 : 123-129.
  • 9GEMPELER- MESSINA PM, MULLER C. Diagnostic use of the pro- tein C activator from Agkistrodon contortrix [ J ]. Tox Rev, 2006,25 : 335-349.
  • 10DUNCAN RE, SARKADI-NAGY E, JAWORSKI K, et al: Identi cation and functional characterization of adipose- specie phospholipase A (AdPLA) [ J]. J Biol Chem,2008 ,283 :25428-25436.

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