固定床“一步法”连续合成对乙酰氨基酚的研究

Study on Continuous Synthesis of N-Acetyl-p-aminophenol by One Step Process in the Fixed-Bed Reactor

:采用钯炭颗粒催化剂 ,研究了固定床“一步法”连续合成对乙酰氨基酚的工艺条件。在催化剂重 0 .50 g,对硝基酚质量分数 5.0 % ,醋酐与对硝基酚的摩尔比为 1 .2～ 1 .4,液时空速 0 .50～ 3.0 0 /h,氢压 1 .0～ 1 .4MPa,反应温度 1 60～ 1 80°C等条件下 ,对硝基酚转化率 1 0 0 % ,成品对乙酰氨基酚选择性达 95.0 %以上。

The conditions of N acetyl p aminophenol (APAP) synthesis by one step process in fixed bed reactor with Pd/C catalyst were studied. The conversion of p nitrophenol (PNP) was 100% and the selectivity of APAP was about 95.0% at temperature 160～180 °C, H 2 pressure 1.0~1.4 MPa, LHSV 0.50~3.0/h, catalyst 0.50 g, mass percent of PNP 5%.