血清IL-6及IL-8水平在中度海拔地区COPD的关系

The significance of serum IL-6 and IL-8 levels in COPD pathogenesis in moderate altitude area

目的观察白介素-6(IL-6)和白介素-8(IL-8)在中度海拔地区慢性阻塞性肺疾病患者血清中的水平,探讨其发病机制中的作用及意义。方法慢性阻塞性肺疾病患者及健康人群中血清IL-6及IL-8水平检测比较。结果①AECOPD组患者血清IL-6及IL-8水平高于稳定期组及对照组(P<0.01);②稳定期组及对照组IL-6及IL-8水平差异无统计学意义(P>0.05)。结论 IL-6及IL-8参与中度海拔地区COPD患者的气道炎症并且与该地区COPD的高发病率有关。

Objective To observe serum IL-6 and IL-8 levels in patients with COPD in order to discuss the significance of IL-6 and IL-8 in COPD pathogenesis in moderate altitude area.Methods Serum IL-6 and IL-8 levels of patients with COPD were tested through the method of double-antibody sandwich ELISA.Result ① IL-6 and IL-8 levels of acute phase of COPD were higher（P〈0.01） than those of the stable phase group and the control group;② Difference of IL-6 and IL-8 levels was no statistically significant（P〉0.05） between the stable phase group and the control group.Conclusion IL-6 and IL-8 involve in the airway inflammation of patients with COPD in moderate altitude area and are concerned with the high incidence of COPD in this area.