三维适形序贯化放疗治疗Ⅲ期非小细胞肺癌的临床观察

Clinical observation on sequential therapy of three-dimensional conformal radiotherapy with chemotherapy in treatment of stage Ⅲ non-small cell lung cance

目的探讨三维适形序贯化放疗治疗Ⅲ期非小细胞肺癌的疗效和不良反应。方法将84例Ⅲ期NSCLC患者随机分为两组:序贯治疗组(A)41例及单纯化疗组(B)43例,A组先采用GP方案化疗,先化疗2周期后行放疗,放疗结束后再行2周期化疗;B组采用GP方案化疗。结果序贯治疗组治疗有效率(CR+PR)68.29%;化疗组治疗有效率(CR+PR)34.88%,两组差异有显著性(P<0.05);1年生存率A组53.66%,B组25.58%,差异有显著性(P<0.05);2年生存率A组19.51%,B组11.63%,差异无显著性。两组病人均能耐受治疗中的不良反应。结论三维适形序贯化放疗可提高晚期NSCLC的近期疗效,毒性反应低,患者耐受性好。

Objective To observe the therapeutic and adverse reactions on sequential therapy of three-dimensional conformal radiotherapy with chemotherapy in treatment of stage Ⅲ non-small cell lung cancer.Methods 84 cases of stage Ⅲ NSCLC were randomized into 2 groups： sequential chemo-radiotherapy group（A） 41 patients and chemotherapy alone group（B） 43 cases,the sequential treatment group was first used GP regimen chemotherapy,the first 2 cycles of chemotherapy underwent radiotherapy after the end of line 2 cycle Chemotherapy,and the Chemotherapy group was used GP regimen chemotherapy.Results The effective rate CR ＋ PR） was 68.29% in sequential chemo-radiotherapy group and 34.88% in chemotherapy group,and the difference was statistically significant（P〈0.05）;1-year survival rate was 53.66% in A and 25.58% in B group,and the difference was significant（P〈0.05）;2-year survival rate was 19.51% in A and 11.63% in B,and the difference was no statistically significant（p 〉0.05）.The toxic effects can be tolerated by all of patients.Conclusion sequential therapy of three-dimensional conformal radiotherapy with chemotherapy can improve short-term effect of non-small cell lung cancer with low toxicity,and the patient tolerate it.