摘要
铁对于机体多种代谢过程至关重要,可催化能量产生、解毒等所需的关键氧化还原反应。它是血红蛋白、肌红蛋白、线粒体电子传递链复合体、细胞色素P450系统和许多其他蛋白质的组成成分。心脏的多种生理过程也需要铁的参与,但过量的铁也可能引起潜在的危害,它可能在多种心血管疾病中起重要作用。本文就铁代谢与心血管疾病的关系作一综述。
出处
《中华临床医师杂志(电子版)》
CAS
2012年第15期141-143,共3页
Chinese Journal of Clinicians(Electronic Edition)
参考文献28
-
1Hentze MW,Muckenthaler MU,Andrews NC. Balancing Acts:olecular Control of Review Mammalian Iron Metabolism[J].Cell,2004,(3):285-297.doi:10.1016/S0092-8674(04)00343-5.
-
2Hentze MW,Muckenthaler MU,Galy B. Two to tango:regulation of mammalian iron metabolism[J].Cell,2010.24-38.doi:10.1016/j.cell.2010.06.028.
-
3Knutson M,Wessling-Resnick M. Iron Metabolism in the eticuloendothelial System[J].Critical Reviews in Biochemistry and Molecular Biology,2003,(1):61-88.doi:10.1080/713609210.
-
4Delaby C,Pilard N,Gon(c)alves AS. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin[J].Blood,2005.3979-3984.
-
5Nemeth E,Tuttle MS,Powelson J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization[J].Science,2004.2090-2093.doi:10.1126/science.1104742.
-
6Zhang AS,Enns CA. Molecular mechanisms of normal iron homeostasis[J].Hematology(American Society Hematology Education Program),2009.207-214.
-
7Qian ZM,Chang YZ,Leung G. Expression of ferroportin1,hephaestin and ceruloplasmin in rat heart[J].Biochimica Et Biophysica Acta,2007,(5):527-532.doi:10.1016/j.bbadis.2007.02.006.
-
8Wallander ML,Leibold EA,Richard S. Molecular control of vertebrate iron homeostasis by iron regulatory proteins[J].Biochimica Et Biophysica Acta,2006.668-689.doi:10.1016/j.bbamcr.2006.05.004.
-
9Kohgo Y,Ikuta K,Ohtake T. Body iron metabolism and pathophysiology of iron overload[J].International Journal of Hematology,2008,(1):7-15.doi:10.1007/s12185-008-0120-5.
-
10Giordano FJ. Oxygen,oxidative stress,hypoxia,and heart failure[J].Journal of Clinical Investigation,2005.500-508.
同被引文献15
-
1Cohen AR, Galanello R, Pennell DJ, et al. Thalassemia [ J ]. Hemalolog.,y Am Soc Hemalol Educ Program ,2004,1:14-34.
-
2Neufeld EJ. Oral chelators deferasirox and deferil>rone for transfusional iron overload in thalassemia major: new data, new queslions[ J ]. Blood,2006, 107:3436-3441.
-
3Wood JC, Otto-Duessel M, Aguilar M, et al. Cardiac irom determines cardiac T1 , T2, and T1 in the gerbil model of iron cardiomyopalhy[ J ]. Circulation,2005, 112:535-543.
-
4Positano V, Salani B, Pepe A, et al. Improved T2* assessment in liver iron overload by magnetle resonance imaging [ J ] . Magn Reson Imaging, 2009, 27:188-197.
-
5Carpenter JP, He T, Kirk P, eL al. On T2*magnetic resonance and cardiac iron[ J]. Circulation, 2011, 123:1519-1528.
-
6Piperno A. Classification and diagnosis of iron overload [J]. Haemalologica, 1998,83:447-455.
-
7Mavrogeni S. Evaluation of myocardial iron overload using magnetic resonance imaging [ J ]. Blood Transfus, 2009, 7: 183-187.
-
8Sheth S. SQUID biosusceptometry in the measurement [ J ]. Pediatr Radio1,2003,33:373-377.
-
9黄才千,仇小强.儿童缺铁性贫血预防策略研究[J].中华疾病控制杂志,2008,12(4):391-394. 被引量:37
-
10林凤茹.慢性病贫血和肾性贫血[J].中国实用内科杂志,2009,29(7):607-610. 被引量:18
引证文献3
-
1黄璐,韩瑞,李志伟,袁思殊,夏黎明.MRI有效横向弛豫时间图对兔心肌铁超负荷模型铁负荷定量的初步研究[J].中华放射学杂志,2014,48(3):236-240. 被引量:6
-
2姜良丽.缺铁性贫血的预防护理[J].中国伤残医学,2014,22(19):187-187. 被引量:1
-
3滕苗苗,伍锋,樊民.补铁治疗在心血管疾病中的作用机制和潜在获益研究进展[J].世界临床药物,2024,45(8):891-896.
二级引证文献7
-
1黄海波,周亚丽,李致忠,管俊,覃明.前瞻性3.0TMRI梯度多回波序列参数优化可行性研究[J].磁共振成像,2015,6(7):529-534. 被引量:4
-
2黄海波,黄桂雄,陈毓秀,李大创,孙熙勇,管俊,覃明.肾脏磁共振梯度多回波-R_2*成像可行性研究[J].磁共振成像,2016,7(1):62-67. 被引量:3
-
3徐丽娜.整体护理用于老年缺铁性贫血护理的效果观察[J].当代医学,2016,22(9):115-116. 被引量:9
-
4邓小强,黄海波,尹晓林,周亚丽,管俊,覃明.地中海贫血患者心肌、肝脏铁沉积与血清铁蛋白相关性研究[J].磁共振成像,2016,7(9):669-674. 被引量:6
-
5黄璐,韩瑞,周舒畅,冉玲平,赵培军,李浩杰,夏黎明.心肌铁过载兔模型心功能的MR评价[J].华中科技大学学报(医学版),2018,47(5):520-525. 被引量:2
-
6黄璐,韩瑞,王思勇,廖茜.长期输血患者心脏、肝脏铁负荷的评估及其与心功能关系的MR研究[J].江西医药,2020,55(4):370-373. 被引量:3
-
7耿薇薇,孙军,潘靓,沙圆圆,王思齐,邱建国.血氧水平依赖磁共振成像评价肾脏铁过载的初步研究[J].中国医学计算机成像杂志,2021,27(3):270-274.
-
1叶伟,王先梅,杨丽霞.脂联素与心血管疾病关系的研究[J].医学综述,2012,18(18):2965-2967. 被引量:7
-
2江春娇,王丽芬,陈江伟.血浆同型半胱氨酸的临床应用[J].健康必读(下),2011(8):95-95.
-
3关璐.胺碘酮相关的甲状腺功能异常[J].中华全科医师杂志,2011,10(12):880-882. 被引量:1
-
4曲萌,董志恒.PARP抑制剂3-AB改善糖尿病大鼠心功能[J].基础医学与临床,2014,34(3):402-403.
-
5张萍,马新见,刘凌云,赵元明.肝硬化患者血清一氧化氮的测定及临床意义[J].医学检验与临床,2004,16(1):37-38.
-
6叶铭宇,刘树滔.糖尿病血管并发症假说的若干进展[J].华夏医学,2003,16(3):424-426. 被引量:1
-
7刘砂,郭敏.活性氧参与心力衰竭发生机制的研究进展[J].心血管康复医学杂志,2015,24(2):222-223. 被引量:4
-
8杨玲.冠状动脉供血不足的心电图表现[J].求医问药(下半月刊),2012,10(2):582-583.
-
9穆绪超.从脾论治餐后高血糖体会[J].实用中医药杂志,2009(9):626-627. 被引量:1
-
10发现华法林代谢的另一遗传因素[J].中国处方药,2005(6):79-79.