摘要
H 1,2,4 Benzothiadiazine 1,1 dioxide derivatives have been widely used in pharmaceutical chemistry.The formation of thiazide ring is a key step for preparing these compounds.Here we described a novel synthesis of the titled compounds in which the thiazide ring is formed conveniently by employing phosphorus oxychloride as dehydrating agent.The structures of the products were characterized by means of elemental analysis, 1HNMR,IR and ultraviolet spectra etc.The total yields of the titled compounds are above 45 percent.
H 1,2,4 Benzothiadiazine 1,1 dioxide derivatives have been widely used in pharmaceutical chemistry.The formation of thiazide ring is a key step for preparing these compounds.Here we described a novel synthesis of the titled compounds in which the thiazide ring is formed conveniently by employing phosphorus oxychloride as dehydrating agent.The structures of the products were characterized by means of elemental analysis, 1HNMR,IR and ultraviolet spectra etc.The total yields of the titled compounds are above 45 percent.
出处
《化学研究与应用》
CAS
CSCD
2000年第3期311-313,共3页
Chemical Research and Application
关键词
合成
2H-1
2
4-苯并噻二嗪-1
1-二氧
利尿
降压
synthesis
2H 1,2,4 benzothiadiazine 1,1 dioxide
phosphorus oxychloride
ringclosure reaction
