依匹斯汀联合组胺人免疫球蛋白治疗慢性荨麻疹疗效观察

Curative Effect of Epinastine Combined with the Histamine Human Immunoglobulin in the Treatment of Chronic Urticaria

目的观察依匹斯汀联合组胺人免疫球蛋白治疗慢性荨麻疹的临床疗效。方法 126例慢性荨麻疹,随机分成两组。治疗组64例,使用依匹斯汀每天睡前口服10mg,同时肌注组胺人免疫球蛋白12mg,隔三天一次;对照组62例,单纯使用依匹斯汀睡前口服10mg,治疗第3周和第6周后判定疗效,停药1个月后观察两组复发情况。结果两组在治疗第3周疗效无显著性差异(P>0.05),第6周后疗效及停药后复发率均有显著性差异(P<0.05),并且不良反应少。结论依匹斯汀联合组胺人免疫球蛋白治疗慢性荨麻疹效果肯定,安全性好,复发率低,为难治性慢性荨麻疹提供一种治疗手段。

Objective To observe the clinical efficacy of epinastine combined with the histamine human immunoglobulin in the treatment of chronic urticaria. Methods 126 cases of chronic urticaria were randomly divided into two groups. The treatment group （64 cases） received epinastine 10 mg orally at bedtime every day and intramuscular injection of histamine human immunoglobulin 12 mg once every three days; the control group （62 cases） received epinastine 10 mg orally at bedtime alone. The curative effect was determined 3 weeks and 6 weeks after the treatment. The recurrences of two groups were observed one month after stopping treatment. Results The difference of curative effect of 3 months after treatment between the two groups was not statistically significant （P〉0.05）; the differences of curative effect of 6 months after treatment and recurrence rate of one month after stopping treatment between the two groups were statistically significant （P 〈0.05）. The treatment group had fewer complications compared with the control group. Conclusions Epinastine combined with histamine human immunoglobulin has certain curative effect, good security and low recurrence rate in the treatment of chronic urticaria, which is a treatment method for refractory chronic urticaria.