预防性应用抗生素在剖宫产术后感染预防中的效果观察

Observation on the Effect of Preventive Application of Antibiotics in the Prevention of Infection after Cesarean Section

目的探讨预防性应用抗生素在剖宫产术后感染预防中的效果。方法选取2010年1月到2011年12月于本院进行剖宫产的170例产妇为研究对象,将其随机分为A组(术后常规应用抗生素组)85例和B组(术前预防性应用抗生素组)85例,将两组患者术后感染发生率、子宫复旧情况、住院时间及术前、术后1d、3d的血清CRP、TNF-α、PCT及IL-6水平进行统计及比较。结果 B组的术后感染发生率低于A组,子宫复旧不佳率低于A组,住院时间短于A组,而术后1d、3d的血清CRP、TNF-α、PCT及IL-6水平均低于A组,P均<0.05,有显著性差异。结论术前预防性应用抗生素在剖宫产中有较高的价值,不仅体现在对术后感染发生率和恢复情况的影响方面,也表现在感染相关因子的控制方面。

Objective To study the effect of preventive application of antibiotics in the prevention of infection after cesarean section. Methods 170 parturients treated with cesarean section in our hospital from March 2011 to February 2012 were selected as research object, and randomly divided into group A （routine application of antibiotics after the surgery group） 85 cases and group B （preventive application of antibiotics before the surgery group） 85 cases, then the infection rate after the surgery, situation of uterine involution,hospitalization time, serum CRP, TNF-a, PCT, IL-6, E-SLT before and after the surgery at first and third day of two groups were analyzed and compared. Results The infection rate after the surgery of group B was lower than that of group A,rates of poor uterine involution,hospitalization time were shorter than that of group A, serum CRP, TNF-a, PCT, and IL-6 after the surgery at first and third day were all lower than those of group A, all P〈0.05, there were all significant differences. Conclusions The value of preventive application of antibiotics in cesarean section before the surgery is higher, and it not only reflects in the influence for the infection rate after cesarean section and recovery situation, but also reflects in the control of related infection factors.