甲氨蝶呤治疗银屑病性关节炎临床观察

Clinical observation of Methotrexate in the treatment of Psoriatic Ar thritis

目的:观察甲氨蝶呤治疗银屑病性关节炎的疗效及不良反应。方法:选符合标准的该病患者59例,随机分为两组。治疗组予甲氨蝶呤治疗。对照组仅用维A酸类药物外用。结果:治疗组治愈11例,显效9例,好转8例,无效4例,总有效率为87.5%(95%CI=65.6～97.8%);对照组治愈2例,显效6例,好转5例,无效14例,总有效率为48.1%(95%CI=29.3～66.9%);两组综合疗效比较(Ⅱ=3.2531,P=0.0015),差异显著。结论:甲氨蝶呤治疗银屑病关节炎的临床疗效明显优于外用维A酸类药物,其收益OR=0.13(95%CI=0.04～0.47),NNT=3(95%CI=1.35～3.54)。

Objective：To observe the curative effect of therapy of Methotrexate on psoriatic arthritis.Method：59 cases of sick children suffered from psoriatic arthritis were divided into twogroups randomly.ne treatment group Was treated by Methotrexate.anther control group Was treated by topical tretinoin.Result：In the treatment group 11 cases were cured,9cases were excellent.8 cases were effective and 4 cases were ineffective.The total effective rate Was 87.5%（95%CI=65.6～97.8%）.In the control group 2 cases were cured,6 cases were excellent,5 cases were effectiveand 14 cases were ineffective.The total effective rate was 48.1%（95%CI=29.3～66.9%）.Thedifference between the two groups Was significant（H=3.253l,P=0.0015）.Conclusion：ne curative effect of Methotrexate with on psoriatic arthritis is better than that of topical tretinoin.OR=0.13（95%CI=0.04～0.47）,NNT=3（95%C11.35～3.54）.