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肝细胞癌自发消退的机制 被引量:3

Mechanisms underlying spontaneous regression of hepatocellular carcinoma
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摘要 本文通过对Medline的搜索,获取自1982年以来肝细胞癌(hepatocellular carcinoma,HCC)自发消退病例85例,对所得病例进行整理、统计和分析,结果显示:免疫是最有可能导致HCC自发消退的原因,其中又以免疫抑制微环境的解除更为关键.缺血、戒酒、输血等都有可能通过解除免疫抑制并激活抗肿瘤免疫而导致HCC的消退. We searched MEDLINE and identified 85 cases of spontaneous regression of hepatocellular carcinoma(HCC).Analysis of these cases found that immunity is the most likely cause of spontaneous regression of HCC,and the elimination of immunosuppressive microenvironment may play a key role in this process.Ischemia,ethanol abstinence,and blood transfusion might lead to regression of HCC through the elimination of immunosuppression and activation of antitumor immunity.
出处 《世界华人消化杂志》 CAS 北大核心 2012年第21期1939-1948,共10页 World Chinese Journal of Digestology
基金 国家自然科学基金资助项目 No.81160264 广西自然科学基金资助项目 No.2010GXNSFD013048~~
关键词 肝细胞癌 自发消退 免疫 微环境 Hepatocellular carcinoma Spontaneousregression Immunity Microenvironment
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