体质量指数与结直肠癌相关性的研究现状

Association between body mass index and colorectal cancer:Recent research progress

结直肠癌(colorectal cancer,CRC)是消化系统常见的严重危害人们健康的杀手,全球每年约有120万新发病例,其中中国约有13万.随着我国社会经济发展和饮食结构的改变,CRC的发病率和死亡率呈逐年上升趋势,且平均发病年龄低于西方国家约20岁,居所有恶性肿瘤中的第2位,在中国发达地区已经接近西方发达国家.CRC的发病是多种因素综合作用的结果,近四分之一的CRC患者可以通过良好的生活习惯来避免患病.目前全球有2/3的成年人正在与超重和肥胖做斗争.近期大量研究表明,高体质量指数(body mass index,BMI)与结直肠癌的发病具有一定关系.本文就BMI与CRC相关性的研究现状作一综述.

Colorectal cancer（CRC） is a common digestive system disease posing a serious threat to people’s health.There are about 1.2 million new cases of CRC diagnosed worldwide each year,and the figure in China is 130 thousand.The socio-economic development and changes in diet and habits in China have led to a significant increase in both the incidence and mortality of CRC.The average age of onset of CRC in China is about 20 years old lower than that in Western countries,ranking second among all malignant tumors.The incidence and mortality of CRC in some developed regions of China,however,is close to those in Western developed countries.The development of CRC results from multiple factors,and nearly a quarter of patients with CRC could have avoided suffering from this disease by making favorable lifestyle habits.Nowadays,two-thirds of adults are fighting against overweight and obesity.Numerous recent studies indicate that high body mass index（BMI） is related with colorectal cancer.This article will review recent advances in understanding the relationship between BMI and CRC.