胃肠道间质瘤的临床特征及治疗进展

Clinical features and treatment of gastrointestinal stromal tumors:Recent advances

胃肠道间质瘤(gastrointestinal stromal tumor,GIST)是胃肠道最常见的间叶性肿瘤,近年来随着分子生物学、组织病理学和临床医学的研究进展,对其认识不断加深.传统手术与分子靶向药物相结合对GIST的治疗显得尤为重要,以伊马替尼和舒尼替尼等药物为代表的多靶点和多激酶抑制剂在治疗不可切除及复发性GIST中更是受到高度关注.本文主要对该病的基因分析、病理组化特点、手术及辅助治疗相关进展作一综述.

Gastrointestinal stromal tumors（GISTs） are the most common gastrointestinal mesenchymal tumors.The development of molecular biology,pathology and clinical medicine in recent years has deepened our understanding of GISTs.The combination of traditional surgery and molecular targeted drugs is particularly important for the treatment of GISTs.Multi-target and multikinase inhibitors such as imatinib and sunitinib have been used for the treatment of unresectable and recurrent GISTs.This paper provides a brief review of gene analysis,pathological characteristics,operational and adjuvant therapy of GISTs.