人巨细胞病毒感染与炎症性肠病的相关研究进展

Progress in understanding the relationship between inflammatory bowel disease and human cytomegalovirus infection

人巨细胞病毒(human cytomegalo virus,HCMV)是普遍存在的DNA病毒,在免疫损伤或免疫抑制的患者中常导致严重疾病.已有研究发现,HCMV在炎症性肠病(inflammatory boweldisease,IBD)的发生和发展中起一定作用.本文综述了近年来有关IBD患者中HCMV感染的临床调查和临床诊断方法,并初步探讨了HCMV感染与IBD发生的相关机制.

Human cytomegalovirus（HCMV） is a ubiquitous DNA virus that can cause severe disease in immunosuppressive or immunocompromised patients.Recent studies have found that CMV might play a role in the pathogenesis and progression of inflammatory bowel disease（IBD）.This paper gives a review of the epidemiology,clinical diagnosis,and pathogenesis of HCMV infection in patients with IBD.