幽门螺杆菌感染与糖化血红蛋白表达相关性的研究进展

Correlation between Helicobacter pylori infection and hemoglobin A1c expression

幽门螺杆菌(Helicobacter pylori,H.pylori)是一种与胃黏膜疾病关系密切的革兰阴性菌,研究发现其与糖尿病、冠心病、缺铁性贫血、特发性血小板减少性紫癜等胃肠外疾病亦紧密相关,然而个中机制却仍不明确.糖化血红蛋白(hemoglobin A1c,HbA1c)是糖尿病(diabetesmellitus,DM)患者血糖水平长期监控的重要指标,研究发现,H.pylori感染阳性的DM患者外周血HbA1c水平较H.pylori阴性DM患者显著升高,这很有可能是H.pylori通过下调胃黏膜瘦素和脑肠肽的表达,造成宿主代谢紊乱和胰岛素抵抗而导致的.关于H.pylori和HbA1c关系的早期研究具有一定的局限性,更为全面、深入的研究势必为H.pylori感染相关性糖尿病的早期防治提供新的方向.

Helicobacter pylori（H.pylori） is a gram-negative bacterium that is closely related with the pathogenesis of chronic gastritis,peptic ulcer,gastric carcinoma as well as many extra-gastrointestinal tract diseases such as coronary heart disease,iron deficiency anemia,idiopathic thrombocytopenic purpura,and diabetes mellitus（DM）.Hemoglobin A1c（HbA1c） level is useful in diagnosing and monitoring DM.Recent studies showed that H.pylori is involved in the up-regulation of HbA1c level in DM patients through modulating the expression of leptin and ghrelin,whose interactions affect obesity,insulin sensitivity,glucose homeostasis and DM.Further studies on the association between H.pylori infection and HbA1c will certainly provide new prospects for early diagnosis and treatment of H.pylori-related DM and its complications.