摘要
转录因子FoxA1通过与染色体结合释放出DNA结合位点对信号转导和细胞增殖进行调控。研究发现多种肿瘤组织中FoxA1表达上调,参与肿瘤生长调控,揭示FoxA1有可能成为新的肿瘤治疗靶点。该研究采用生物信息学方法,在获得FoxA1基因和蛋白序列的基础上,对其结构、性质以及与其有相互作用的蛋白进行初步的生物信息学分析,以期为进一步研究FoxA1的生物学特性奠定基础。
Transcription factor FoxA1 is a ＇pioneer＇ factor that binds to chromatinized DNA and regulates cell signaling and ceil cycle. High expression of FoxAl has been reported in various tumors, and it maybe a potential therapeutic target of the cancer. This study aimed to obtain more information about FoxA1. The structures and functions, protein interaction network, multiple sequence alignment were analyzed with soft- ware tools and database. We obtained more biological information about FoxA1 protein by bioinformatic analysis, which is very useful for fur- ther research.
出处
《安徽农业科学》
CAS
2012年第24期11953-11956,共4页
Journal of Anhui Agricultural Sciences
基金
徐州市科技基金资助项目(XZZD1146)
关键词
FoxA1
转录因子
生物信息学
肿瘤
FoxAlprotein
Transcription factor
Bioinformatic analysis
Cancer
