摘要
目的探讨荧光素钠引导在脑胶质瘤切除中的应用。方法对10例脑胶质瘤患者术中应用荧光素钠将肿瘤染色，根据荧光染色强度判定肿瘤的边界并切除。结果星形细胞瘤（WHOⅡ级）4例，间变性星形细胞瘤（WHOⅢ级）、胶质母细胞瘤（WHⅣ级）各3例，术中肿瘤切除范围与病理学检查相符，术后1周MRI增强扫描显示肿瘤全切除8例，次全切除2例。术后语言肢体运动障碍一过性加重3例，给予对症治疗后逐渐恢复。结论该方法应用简便、安全、经济，对高级别胶质瘤术中可直观、实时判断肿瘤的边界，大大提高了肿瘤切除率。
Objective To investigate the effects of fluorescence guiding removal in glioma surgery. Methods Ten gliomas were removed assisted by fluorescence guiding. The gliomas were stained with flnoreseein sodium and presented yellow color. Based on the intensity of fluorescence, the gliomas were dissected strictly along the boundary between the glioma and normal brain tissues. Results The pathological examination showed that 4 cases were astrocytoma （WHO grade two ）, 6 anaplastic astrocytomas and glioblastomas. The extent of glioma ＂s removal was consistent with histo - pathological examination. Postoperatively, enhanced MRI showed that the tumors were radically removed in 8 cases and subtotal in 2. KPS evaluation showed that seven patients improved significantly, three remained or complicated temporarily with movement or lingual disturbance, but they all recovered gradually after treatment. Conclusions Fluo- rescence- guided glioma removal is a simple, safe and economic method, which will make neurosurgeons find easily the boundary between the higher grade gliomas and the normal tissues. It contributes to the removal effects of glioms.
出处
《中华神经外科杂志》
CSCD
北大核心
2012年第8期829-831,共3页
Chinese Journal of Neurosurgery
