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肾上腺髓质素在黑素瘤中的表达 被引量：2

Expression of ADM in malignant melanoma
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摘要 目的:检测肾上腺髓质素(adrenomedulin,ADM)在人黑素瘤中的表达。方法:采用免疫组织化学SP法检测ADM在15例黑素瘤、30例色素痣组织标本及人成纤维细胞、黑素瘤细胞系A375中的表达。结果:人成纤维细胞中ADM的表达为弱阳性、A375中ADM表达呈强阳性。黑素瘤组织标本中80%检测到ADM,色素痣组织标本中仅有43.3%检测到ADM的表达,差异有统计学意义(P<0.05)。结论:肾上腺髓质素在人黑素瘤组织中高表达,在人的色素痣和成纤维细胞中低表达,提示ADM与黑素瘤发生、发展可能密切相关。 Objective： To investigate the expression of adrenomedtdlin （ADM） protein in human malignant melanoma. Methods： The expression of ADM in cell lines A375, fibroblast of human, malignant melanoma and cutaneous naevi are detected with SP immunohistochemistry method. Results： The expression of ADM in A375 is higher than in fibroblast. The positive expression of ADM was found 12 cases （80%） in 15 cases malignant melanoma and 13 cases （43.3%） in 30 cases of cutaneous naevi, with a significant difference （ P 〈 0.05）. Conclusion： The expression of ADM significantly increase in A375 and in malignant melanoma organization specimen but in cutaneous naevi and fibroblast the expression ADM are weak, suggesting that ADM may correlate close with the tumorigenesis and progress of malignant melanoma.
作者 李志加 孙立新 陆洁 段昕所
机构地区 承德医学院附属医院
出处 《中国麻风皮肤病杂志》 2012年第8期551-553,共3页 China Journal of Leprosy and Skin Diseases
关键词 黑素瘤 色素痣 肾上腺髓质素 成纤维细胞 免疫组织化学 malignant melanoma cutaneous naevi adrenomedullin fibroblast immunohistochemistry
分类号 R739.5 [医药卫生—肿瘤]
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  • 2Miyashita K, Itoh H, Sawada N, et al. Adrenomedullin promotesprolif-eration and migration of cultured endothelial cells. Hypertens Res, 2003, 26 (Suppl) : S93-98.
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同被引文献19

  • 1温雪萍,李艳,黄绍光,颜志军,王忠慧,丁梅芬,赵家美.肾上腺髓质素在肺癌患者中的表达及其临床意义[J].中国临床医学,2006,13(6):912-913. 被引量：2
  • 2Miller MJ, Martinez A, Unsworth EJ, et al. Adrenomedullin expression in human tumor cell lines. Its potential role as an autocfine growth factor. J Biol Chem, 1996, 271 (38): 23345- 23351.
  • 3Zudaire E, Martinez A, Cuttitta F. Adrenomedullin and canncer. Regul Pept, 2003, 112(1-3): 175-183.
  • 4Ouafik L, Sauze S, Boudouresque F, et al.Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo. Am J Pathol, 2002, 160(4): 1279-1292.
  • 5Mazzocchi G, Malendowicz LK, Ziolkowska A, et al. Adrenomedullin (AM) and AM receptor type 2 expression is up-regulated in prostate carcinomas (PC), and AM stimulates in vitro growth of a PC-derived cell line by enhancing proliferation and decreasing apoptosis rates. Int J Oncol, 2004, 25(6): 1781-1787.
  • 6Uemura M, Yamamoto H, Takemasa I, et al. Hypoxia-inducible adrenomedullin in colorectal cancer. Anticancer Res, 2011, 31 (2): 507-514.
  • 7Chen P, Huang Y, Bong R, et al. Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner. Clin Cancer Res, 2011, 17 (23): 7230-7239.
  • 8Martinez A, Vos M, Guedez L, el al. The effects of adrenomedullin overexpression in breast tumor cells. J Natl Cancer Inst, 2002, 94 (16): 1226-1237.
  • 9Oehler MK, Norbury C, Hague S, et al. Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer ceils: a possible promotion mechanism for tumour growth. Oncogene, 2001, 20(23): 2937-2945.
  • 10Chen P, Huang Y, Bong R, et al. Tumor- associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paraerine and au- toerine manner[J]. Clin Cancer,2011,17(23) :7230-7239.

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中国麻风皮肤病杂志
2012年 第8期

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