氟比洛芬酯脂微球注射液对急性肾绞痛的镇痛效果观察

The analgesic effect of observation on Fluorine finn ester microspheres cells-recognition of injection of acute renal colic

目的观察与研究氟比洛芬酯脂微球注射液治疗急性肾绞痛的疗效。方法本文选择了本院2009年1月1日～2010年12月31日收治的150例急性肾绞痛患者进行研究,采用完全随机的方法,将患者分为3组,每组50例,A组患者给予50mg氟比洛芬酯脂微球注射液进行静脉注射;B组患者给予100mg哌替啶肌注;C组患者给予氟比洛芬酯脂微球注射液25mg静注联合哌替啶50mg肌注,比较和观察3组患者使用药物的镇痛效果以及副反应。结果 A组患者治疗后的总有效率为93.5%,B组患者治疗后的总有效率为91.3%,C组患者治疗后的总有效率为92.3%,经χ2检验,各组之间的差异无统计学意义。在镇痛持续时间方面,A组(14.8±3.9)h,B组(13.3±1.1)h,C组(20.4±1.4)h,各组之间的差异具有统计学意义。各组之间副反应不具有统计学意义。结论氟比洛芬酯脂微球治疗急性肾绞痛的疗效与哌替啶的疗效相比镇痛效果相当,与哌替啶相比其起效时间更为迅速,同时更加安全,副反应少,是一种治疗急性肾绞痛的有效、安全的措施,值得在临床上实施与推广。

Objective To observe and research the efficacy of flurbiprofen axetil injection in acute renal colic. Methods One hundred and fifty cases of acute renal colic from January 1, 2009 to December 31, 2010 were chosen. They were randomly divided into three group, each group of 50 cases. The flutrbiprofen axetil injection 50 mg were giver by I.V injection in group A. The meperidine injection 100 mg were given by I.M. in group B. The flutrbiprofen axetil injection 25 mg were giver hy I.V combined with the meperidine injection 50 mg were given by I.M. injection in group C. The analgesic effect and side reaction of drugs were observed comparatively among three groups. Results The total effective rate of group A, B and C were 93.5%, 91.3% and 92.3% respectively. Via X2 test, there was no significant difference among these groups statistically. Anaigesic continuous time of group A, B and C were （14.8＋3,9） hours, （13.3±1.1） hours and （20.4±1.4） hours respectively, and there was significant difference among the three groups. Conclusion In the treatment of acute renal colic, both flurbiprofen axeti and meperidine injection possesses same good analgesic effect, compare with the meperidine, the work time more quickly, at the same time, it is more secure and less side effect. It is worthy of clinical application and promotion.