生育因素与绝经后妇女代谢综合征患病风险的关系

Relationship between reproductive factors and risk of metabolic syndrome in postmenopausal women

目的：探讨生育因素与绝经后妇女代谢综合征患病风险之间的关系。方法：716名绝经后妇女纳入本研究，通过问卷调查采集其生育因素．同时检测生化指标。代谢综合征定义采用按照亚洲人特点改良的美国国家胆固醇教育计划成人治疗组第3次报告（NCEP．ATPni）诊断标准。采用多元逐步回归和多因素Logistic回归分析生育因素与代谢综合征及其组分之间的关系。结果：本研究人群代谢综合征患病率为43．85％。患有代谢综合征的绝经后妇女初潮年龄明显小于无代谢综合征组（P=0．0011）。多元Logistic回归结果显示。随着初潮年龄的增加，代谢综合征的患病风险下降[比值比（OR）=0．858；95％可信区间（CI）：0．752．0．9801。而其他生育因素，包括绝经年龄、停经年限、怀孕次数、是否哺乳、哺乳时间、口服避孕药或激素替代治疗等则与代谢综合征的患病风险无关。结论：在各种生育因素中．初潮年龄小提示绝经后妇女代谢综合征的患病风险高。

Objective To evaluate the association between reproductive factors and risk of metabolic syndrome in postmenopausal women. Methods A total of 716 postmenopausal women were enrolled in this study. Reproductive factors were collected by questionnaire interview. Biochemical features were evaluated at the same time, and metabolic syndrome was defined according to the National Cholesterol Educational Program Adult Treatment Penal ]lI （NCEP-ATP III） criteria with modification on waist circumference cutoff value to be more appropriate for Asian population. Results Metabolic syndrome was present in 43.85% of the study participants. Compared with women without metabolic syndrome, women with metabolic syndrome had a younger age of menarche. Results of Logistic regression analysis showed that after adjustment for multiple confounding factors, age of menarche was correlated with the risk of metabolic syndrome [odds ratio （OR）=0.858; 95% confidence interval（CI）： 0.752-0.980]. However, other reproductive factors including age at menopause, years since menopause, number of pregnancy, lactation, duration of lactation, oral contraceptive and hormone replacement therapy were not correlated with metabolic syndrome. Conclusions Among various reproductive factors, younger age of menarche was associated with an increased risk of metabolic syndrome in postmenopausal women.