单胎与多胎妊娠卵巢过度刺激综合征的临床分析

Clinical Analysis of Single and Multiple Fetus Pregnancy Complicated with Ovarian Hyperstimulation Syndrome

目的:探讨辅助生殖技术中的卵巢过度刺激综合征(0HSS)患者中单胎与多胎妊娠的临床特征及妊娠结局。方法:对2005年1月至2011年1月在我院生殖中心行常规体外受精-胚胎移植(IVF-ET)/单精子胞浆内注射(ICSI)治疗周期中发生OHSS住院治疗的52例单胎及96例多胎患者进行回顾性分析,比较两组患者的临床特征。结果:①多胎妊娠患者较单胎OHSS病程长、肝肾功能损害大、白蛋白使用率高(P<0.01,P<0.05),多胎的胸腹水发生率及胸腔穿刺率较单胎高(P<0.05)。②多胎妊娠与单胎妊娠OHSS患者的结局比较:多胎妊娠的流产率及早产率均较单胎妊娠高(P<0.05,P<0.01)。结论:多胎妊娠会加重并延长OHSS的临床病情,并对妊娠结局产生不利影响,控制好胚胎移植数量是预防OHSS发生的关键环节。

Objective： To investigate the clinical manifestations and pregnancy outcomes of single and multiple fetus pregnancy complicated with ovarian hyperstimulation syndrome（OHSS） after IVF-ET or ICSI. Methods ： 52 cases of single fetus and 96 cases of multiple pregnancy complicated with OHSS after IVF-ET or ICSI from January 2005 to January 2011 in the Reproductive Center of our hospital were retrospectively analyzed. Results ： Multiple fetus pregnancy had longer disease process, more severe symptoms, more usage of albumin for treatment of OHSS, higher incidence rates of ascites and hydrothorax, more chest puncture than single fetus pregnancy（ P 〈 0.05, P 〈 0.01 ）. The rates of miscarriage and premature deliv- ery were higher in multiple pregnancy than those in single pregnancy（ P 〈0.05, P 〈0. 01 ）. Conclusions：Mul- tiple pregnancywill worsen and prolong the clinical process of OHSS, even cause adverse pregnancy out- comes, so controlling the number of embryo transfer is crucial for the prevention of OHSS.