急性冠脉综合征患者血清肝细胞生长因子的测定及临床意义

Clinical significance of serum hepatocyte growth factor level in patients with acute coronary syndrome

目的:探讨急性冠脉综合征(ACS)患者血清肝细胞生长因子(HGF)水平变化的临床意义。方法:160例住院患者分为急性心肌梗死(AMI)、不稳定型心绞痛(UA)、稳定型心绞痛(SA)及对照组(C),检测各组血清HGF水平。随访ACS患者5年内不良心血管事件的发生情况。结果:ACS患者早期血清HGF水平明显升高,发生不良心血管事件者血清HGF水平与未发生者有显著差异。结论:血清HGF浓度对ACS的早期诊断、危险分层及预后均有重要意义。

Objective： To patients with acute coronary myocardial infarction group （ 20） and control group （C, investigate the clinical significance of serum hepatocyte growth factor （HGF） level in syndrome （ACS）. Methods： A total of 160 patients were divided into acute AMI, n = 60）, unstable angina group （UA, n = 60）, stable angina group （SA, n = n = 20）. The serum HGF concentration was measured for all patients. The major adverse cardiovascular event （MACE） was observed in 5 years for ACS patients. Results： Serum HGF level was significantly higher in the patients with ACS. There was a significant difference in serum HGF levels between ACS patients with and without MACE. Conclusion： The HGF level might play an important role in early diagnosis and assessing the status and prognosis of ACS.