深圳市某地2011年正常人群手足口病隐性感染调查研究

Investigation of the HFMD carrier status of healthy adults and children in a district of Shenzhen,2011

目的了解深圳市某地2011年成人及健康儿童手足口病隐性感染情况,探讨健康人群隐性感染与儿童患手足口病的关系。方法随机选取该区域幼儿园学生和老师共150人,分为0～、2～、5～岁组各30人,15～、24～、>50岁组各20人。每人采集粪便标本5～8g,进行肠道病毒通用型、肠道病毒71型(EV71)、柯萨奇病毒A16型(CA16)核酸检测。结果共采集150份样本,EV通用型阳性13份(8.67%),其中5岁以下的有11例(84.6%)。CA16阳性2份,EV71阳性1份,均属于0～岁组。结论肠道病毒在人群中隐性感染较为普遍,5岁以内儿童为主要感染人群。健康人群中引起手足口病常见的EV71和CA16阳性肠道病毒隐性感染率低。

Objectives To understand the epidemic situation of the carrier status of hand-foot and mouth disease （HFMD） in healthy adults and children in a district of Shenzhen, 2011. Investigating the relationship between the recessive infection in healthy adults and children suffer from HFMD. Methods Randomly selected kindergarten students and teachers in the region from May to November were selected for this surevy. The subjects were divided into 6 age groups, namely 0~,2- and 5- years old group （30 people per group）;15-, 24~ and 50 years old group （20 people per group）. Five to eight grams of feces were collected from each people for the enterovirus nucleic acid detection （including EV71 and CA16 sub type）. Results 150 samples was collected, 13 specimens were Universal Enterovirus positive, the positive rate was 8.67%, among which 11 positive cases （84.6%） were under 5 years old. Two specimens were CA16 subtype positive and only 1 specimen （aged 0-） was EV71 subtype positive. Conclusions Intestinal viral infection is common in the population. Children under the age of 5 were at high risk of infection. The carrier status of CA16 and EV71 in the healthy population was not significant.