CA125和AFP与卵巢未成熟畸胎瘤的相关性研究

The Correlation between Serum Levels of CA125 and AFP and Immature Teratoma of the Ovary

目的探讨血清糖链蛋白125(carbohydrate antigen 125,CA125)、甲胎蛋白(alpha-fetoprotein,AFP)与卵巢未成熟畸胎瘤(immature teratoma of the ovary,IT)的相关性.方法测定102例单纯型卵巢畸胎瘤的血清CA125、血清AFP,并按手术后病理结果分为IT 32例,卵巢成熟畸胎瘤(mature cys tic teratoma of the o-vary,MCT)70例,分析CA125、AFP检测水平在卵巢成熟及未成熟畸胎瘤诊断中的差异,并对30例未成熟畸胎瘤进行随访,评价CA125,AFP在复发病例中的作用.结果 IT的CA125、AFP平均水平及敏感性均高于MCT,差异有统计学意义(P<0.01).AFP在卵巢未成熟畸胎瘤术后复发病例中下降不明显.结论 CA125、AFP联合检测对卵巢未成熟型与成熟型畸胎瘤的鉴别诊断有一定参考价值;AFP可能是评价卵巢未成熟畸胎瘤早期复发及判断预后的指标.

Objective To disscuss the correlation between immature teratoma of the ovary and serum CA125 or AFP. Methods The serum levels of CA125 and AFP were measured in 102 patients with simple ovarian teratoma. The patients were divided into 32 cases of ovarian immature teratoma and 70 cases of ovarian mature teratoma according to surgery and pathology results. The serum levels of CA125 and AFP were compared between two groups. The 30 cases of immature teratoma were followed up, and the roles of CA125 and AFP in the recurrence were compared. Results The average levels and sensitivity of CA125 and AFP in patients with immature teratoma were higher than in patients with mature teratoma, the difference was statistically significant （P 〈 0.01 ）. The decrease of AFP levels in the recurrence of cases of ovarian immature teratoma was not obvious. Conclusions CA125 and AFP have some reference value in the differential diagnosis of immature and mature ovarian teratoma. AFP may be an indicator of the early recurrence and prognosis of ovarian immature teratoma.