米非司酮治疗胎盘粘连及胎盘植入80例

Treatment with Mifepristone for Placenta Accreta and Placenta Increta in 80 Patients

目的探讨米非司酮在胎盘粘连和植入中的临床疗效及应用价值.方法回顾性分析97例临床资料,其中治疗组80例口服米非司酮,对胎盘植入面积和深度、用药剂量、疗程、出血量、B超、血β-HCG、肝肾功、副作用等方面进行探讨.结果米非司酮治疗胎盘粘连和植入成功率100%,表现为阴道流血少,子宫复旧好,血β-HCG正常,B超检查宫腔无异常回音,基底血流信号消失,患者血常规、肝肾功能正常.少数病例出现恶心、头痛,未经处理自行好转.结论米非司酮治疗胎盘粘连及胎盘植入疗效确切,用药方便,副作用小,值得临床推广运用.

Objective To discuss the clinical effects and the application value of Mifepristone for placenta accreta and placenta increta. Methods The clinical data of 97 patients with placenta accreta and placenta increta, including 80 patients in treatment group who were treated with Mifepristone, the implanted placenta area and depth, the dose and course, the amount of bleeding after childbirth, the B ultrasonic examination results, [3 -HCG, hepatic/renal function and side effect were analyzed. Results The success rate was 100%. It showed that colpor- rhagia reduced, uterine recuperated well, 13 -HCG was in normal level. There was no abnormal uterine reply with B ultrasonic examination and base flow signals disappeared. The blood normal tests and hepatic/renal function were normal. A few patients felt sick and headache, but were spontaneously improved without treatment. Conclu- sion Nonsurgical treatment with Mifepristone possesses a better result for placenta accreta and placenta increta with rapid initial effect, no side effect, convenience and no contraindications.